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Novel biomarkers of ciliary extracellular vesicles interact with ciliopathy and Alzheimer’s associated proteins

Ciliary extracellular vesicles (ciEVs), released from primary cilia, contain functional proteins that play an important role in cilia structure and functions. We have recently shown that ciEVs and cytosolic extracellular vesicles (cyEVs) have unique and distinct biomarkers. While ciEV biomarkers hav...

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Detalles Bibliográficos
Autores principales: Mohieldin, Ashraf M., Alachkar, Amal, Yates, John, Nauli, Surya M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726672/
https://www.ncbi.nlm.nih.gov/pubmed/34992713
http://dx.doi.org/10.1080/19420889.2021.2017099
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author Mohieldin, Ashraf M.
Alachkar, Amal
Yates, John
Nauli, Surya M.
author_facet Mohieldin, Ashraf M.
Alachkar, Amal
Yates, John
Nauli, Surya M.
author_sort Mohieldin, Ashraf M.
collection PubMed
description Ciliary extracellular vesicles (ciEVs), released from primary cilia, contain functional proteins that play an important role in cilia structure and functions. We have recently shown that ciEVs and cytosolic extracellular vesicles (cyEVs) have unique and distinct biomarkers. While ciEV biomarkers have shown some interactions with known ciliary proteins, little is known about the interaction of ciEV proteins with proteins involved in ciliopathy and neurodegenerative disorders. Here, we reveal for the first time the protein-protein interaction (PPI) between the top five ciEVs biomarkers with ciliopathy and Alzheimer disease (AD) proteins. These results support the growing evidence of the critical physiological roles of cilia in neurodegenerative disorders.
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spelling pubmed-87266722022-01-05 Novel biomarkers of ciliary extracellular vesicles interact with ciliopathy and Alzheimer’s associated proteins Mohieldin, Ashraf M. Alachkar, Amal Yates, John Nauli, Surya M. Commun Integr Biol Research Article Ciliary extracellular vesicles (ciEVs), released from primary cilia, contain functional proteins that play an important role in cilia structure and functions. We have recently shown that ciEVs and cytosolic extracellular vesicles (cyEVs) have unique and distinct biomarkers. While ciEV biomarkers have shown some interactions with known ciliary proteins, little is known about the interaction of ciEV proteins with proteins involved in ciliopathy and neurodegenerative disorders. Here, we reveal for the first time the protein-protein interaction (PPI) between the top five ciEVs biomarkers with ciliopathy and Alzheimer disease (AD) proteins. These results support the growing evidence of the critical physiological roles of cilia in neurodegenerative disorders. Taylor & Francis 2021-12-25 /pmc/articles/PMC8726672/ /pubmed/34992713 http://dx.doi.org/10.1080/19420889.2021.2017099 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mohieldin, Ashraf M.
Alachkar, Amal
Yates, John
Nauli, Surya M.
Novel biomarkers of ciliary extracellular vesicles interact with ciliopathy and Alzheimer’s associated proteins
title Novel biomarkers of ciliary extracellular vesicles interact with ciliopathy and Alzheimer’s associated proteins
title_full Novel biomarkers of ciliary extracellular vesicles interact with ciliopathy and Alzheimer’s associated proteins
title_fullStr Novel biomarkers of ciliary extracellular vesicles interact with ciliopathy and Alzheimer’s associated proteins
title_full_unstemmed Novel biomarkers of ciliary extracellular vesicles interact with ciliopathy and Alzheimer’s associated proteins
title_short Novel biomarkers of ciliary extracellular vesicles interact with ciliopathy and Alzheimer’s associated proteins
title_sort novel biomarkers of ciliary extracellular vesicles interact with ciliopathy and alzheimer’s associated proteins
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726672/
https://www.ncbi.nlm.nih.gov/pubmed/34992713
http://dx.doi.org/10.1080/19420889.2021.2017099
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