Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology

Parkinson disease (PD)-affected brains show consistent endoplasmic reticulum (ER) stress and mitophagic dysfunctions. The mechanisms underlying these perturbations and how they are directly linked remain a matter of questions. XBP1 is a transcription factor activated upon ER stress after unconventio...

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Detalles Bibliográficos
Autores principales: El Manaa, Wejdane, Duplan, Eric, Goiran, Thomas, Lauritzen, Inger, Vaillant Beuchot, Loan, Lacas-Gervais, Sandra, Morais, Vanessa Alexandra, You, Han, Qi, Ling, Salazar, Mario, Ozcan, Umut, Chami, Mounia, Checler, Frédéric, Alves da Costa, Cristine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726674/
https://www.ncbi.nlm.nih.gov/pubmed/34030589
http://dx.doi.org/10.1080/15548627.2021.1917129

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