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Mammal virus diversity estimates are unstable due to accelerating discovery effort
Host-virus association data underpin research into the distribution and eco-evolutionary correlates of viral diversity and zoonotic risk across host species. However, current knowledge of the wildlife virome is inherently constrained by historical discovery effort, and there are concerns that the re...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727147/ https://www.ncbi.nlm.nih.gov/pubmed/34982955 http://dx.doi.org/10.1098/rsbl.2021.0427 |
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author | Gibb, Rory Albery, Gregory F. Mollentze, Nardus Eskew, Evan A. Brierley, Liam Ryan, Sadie J. Seifert, Stephanie N. Carlson, Colin J. |
author_facet | Gibb, Rory Albery, Gregory F. Mollentze, Nardus Eskew, Evan A. Brierley, Liam Ryan, Sadie J. Seifert, Stephanie N. Carlson, Colin J. |
author_sort | Gibb, Rory |
collection | PubMed |
description | Host-virus association data underpin research into the distribution and eco-evolutionary correlates of viral diversity and zoonotic risk across host species. However, current knowledge of the wildlife virome is inherently constrained by historical discovery effort, and there are concerns that the reliability of ecological inference from host-virus data may be undermined by taxonomic and geographical sampling biases. Here, we evaluate whether current estimates of host-level viral diversity in wild mammals are stable enough to be considered biologically meaningful, by analysing a comprehensive dataset of discovery dates of 6571 unique mammal host-virus associations between 1930 and 2018. We show that virus discovery rates in mammal hosts are either constant or accelerating, with little evidence of declines towards viral richness asymptotes, even in highly sampled hosts. Consequently, inference of relative viral richness across host species has been unstable over time, particularly in bats, where intensified surveillance since the early 2000s caused a rapid rearrangement of species' ranked viral richness. Our results illustrate that comparative inference of host-level virus diversity across mammals is highly sensitive to even short-term changes in sampling effort. We advise caution to avoid overinterpreting patterns in current data, since it is feasible that an analysis conducted today could draw quite different conclusions than one conducted only a decade ago. |
format | Online Article Text |
id | pubmed-8727147 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-87271472022-01-08 Mammal virus diversity estimates are unstable due to accelerating discovery effort Gibb, Rory Albery, Gregory F. Mollentze, Nardus Eskew, Evan A. Brierley, Liam Ryan, Sadie J. Seifert, Stephanie N. Carlson, Colin J. Biol Lett Pathogen Biology Host-virus association data underpin research into the distribution and eco-evolutionary correlates of viral diversity and zoonotic risk across host species. However, current knowledge of the wildlife virome is inherently constrained by historical discovery effort, and there are concerns that the reliability of ecological inference from host-virus data may be undermined by taxonomic and geographical sampling biases. Here, we evaluate whether current estimates of host-level viral diversity in wild mammals are stable enough to be considered biologically meaningful, by analysing a comprehensive dataset of discovery dates of 6571 unique mammal host-virus associations between 1930 and 2018. We show that virus discovery rates in mammal hosts are either constant or accelerating, with little evidence of declines towards viral richness asymptotes, even in highly sampled hosts. Consequently, inference of relative viral richness across host species has been unstable over time, particularly in bats, where intensified surveillance since the early 2000s caused a rapid rearrangement of species' ranked viral richness. Our results illustrate that comparative inference of host-level virus diversity across mammals is highly sensitive to even short-term changes in sampling effort. We advise caution to avoid overinterpreting patterns in current data, since it is feasible that an analysis conducted today could draw quite different conclusions than one conducted only a decade ago. The Royal Society 2022-01-05 /pmc/articles/PMC8727147/ /pubmed/34982955 http://dx.doi.org/10.1098/rsbl.2021.0427 Text en © 2022 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Pathogen Biology Gibb, Rory Albery, Gregory F. Mollentze, Nardus Eskew, Evan A. Brierley, Liam Ryan, Sadie J. Seifert, Stephanie N. Carlson, Colin J. Mammal virus diversity estimates are unstable due to accelerating discovery effort |
title | Mammal virus diversity estimates are unstable due to accelerating discovery effort |
title_full | Mammal virus diversity estimates are unstable due to accelerating discovery effort |
title_fullStr | Mammal virus diversity estimates are unstable due to accelerating discovery effort |
title_full_unstemmed | Mammal virus diversity estimates are unstable due to accelerating discovery effort |
title_short | Mammal virus diversity estimates are unstable due to accelerating discovery effort |
title_sort | mammal virus diversity estimates are unstable due to accelerating discovery effort |
topic | Pathogen Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727147/ https://www.ncbi.nlm.nih.gov/pubmed/34982955 http://dx.doi.org/10.1098/rsbl.2021.0427 |
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