Human genetic variant E756del in the ion channel PIEZO1 not associated with protection from severe malaria in a large Ghanaian study

Recently, a common genetic variant E756del in the human gene PIEZO1 was associated with protection from severe malaria. Here, we performed a genetic association study of this gain-of-function variant in a large case-control study including 4149 children from the Ashanti Region in Ghana, West Africa....

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Autores principales: Thye, Thorsten, Evans, Jennifer A., Ruge, Gerd, Loag, Wibke, Ansong, Daniel, Agbenyega, Tsiri, Horstmann, Rolf D., May, Jürgen, Schuldt, Kathrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727285/
https://www.ncbi.nlm.nih.gov/pubmed/34230590
http://dx.doi.org/10.1038/s10038-021-00958-2
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author Thye, Thorsten
Evans, Jennifer A.
Ruge, Gerd
Loag, Wibke
Ansong, Daniel
Agbenyega, Tsiri
Horstmann, Rolf D.
May, Jürgen
Schuldt, Kathrin
author_facet Thye, Thorsten
Evans, Jennifer A.
Ruge, Gerd
Loag, Wibke
Ansong, Daniel
Agbenyega, Tsiri
Horstmann, Rolf D.
May, Jürgen
Schuldt, Kathrin
author_sort Thye, Thorsten
collection PubMed
description Recently, a common genetic variant E756del in the human gene PIEZO1 was associated with protection from severe malaria. Here, we performed a genetic association study of this gain-of-function variant in a large case-control study including 4149 children from the Ashanti Region in Ghana, West Africa. The statistical analysis did not indicate an association with protection from severe malaria and, thus, providing evidence against a strong protective effect of the PIEZO1 E756del variant on severe malaria susceptibility.
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spelling pubmed-87272852022-01-18 Human genetic variant E756del in the ion channel PIEZO1 not associated with protection from severe malaria in a large Ghanaian study Thye, Thorsten Evans, Jennifer A. Ruge, Gerd Loag, Wibke Ansong, Daniel Agbenyega, Tsiri Horstmann, Rolf D. May, Jürgen Schuldt, Kathrin J Hum Genet Brief Communication Recently, a common genetic variant E756del in the human gene PIEZO1 was associated with protection from severe malaria. Here, we performed a genetic association study of this gain-of-function variant in a large case-control study including 4149 children from the Ashanti Region in Ghana, West Africa. The statistical analysis did not indicate an association with protection from severe malaria and, thus, providing evidence against a strong protective effect of the PIEZO1 E756del variant on severe malaria susceptibility. Springer Singapore 2021-07-07 2022 /pmc/articles/PMC8727285/ /pubmed/34230590 http://dx.doi.org/10.1038/s10038-021-00958-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Thye, Thorsten
Evans, Jennifer A.
Ruge, Gerd
Loag, Wibke
Ansong, Daniel
Agbenyega, Tsiri
Horstmann, Rolf D.
May, Jürgen
Schuldt, Kathrin
Human genetic variant E756del in the ion channel PIEZO1 not associated with protection from severe malaria in a large Ghanaian study
title Human genetic variant E756del in the ion channel PIEZO1 not associated with protection from severe malaria in a large Ghanaian study
title_full Human genetic variant E756del in the ion channel PIEZO1 not associated with protection from severe malaria in a large Ghanaian study
title_fullStr Human genetic variant E756del in the ion channel PIEZO1 not associated with protection from severe malaria in a large Ghanaian study
title_full_unstemmed Human genetic variant E756del in the ion channel PIEZO1 not associated with protection from severe malaria in a large Ghanaian study
title_short Human genetic variant E756del in the ion channel PIEZO1 not associated with protection from severe malaria in a large Ghanaian study
title_sort human genetic variant e756del in the ion channel piezo1 not associated with protection from severe malaria in a large ghanaian study
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727285/
https://www.ncbi.nlm.nih.gov/pubmed/34230590
http://dx.doi.org/10.1038/s10038-021-00958-2
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