The RNA-binding protein IGF2BP3 is critical for MLL-AF4-mediated leukemogenesis

Despite recent advances in therapeutic approaches, patients with MLL-rearranged leukemia still have poor outcomes. Here, we find that the RNA-binding protein IGF2BP3, which is overexpressed in MLL-translocated leukemia, strongly amplifies MLL-Af4-mediated leukemogenesis. Deletion of Igf2bp3 signific...

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Detalles Bibliográficos
Autores principales: Tran, Tiffany M., Philipp, Julia, Bassi, Jaspal Singh, Nibber, Neha, Draper, Jolene M., Lin, Tasha L., Palanichamy, Jayanth Kumar, Jaiswal, Amit Kumar, Silva, Oscar, Paing, May, King, Jennifer, Katzman, Sol, Sanford, Jeremy R., Rao, Dinesh S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727287/
https://www.ncbi.nlm.nih.gov/pubmed/34321607
http://dx.doi.org/10.1038/s41375-021-01346-7

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