Identification and characterization of relapse-initiating cells in MLL-rearranged infant ALL by single-cell transcriptomics

Infants with MLL-rearranged infant acute lymphoblastic leukemia (MLL-r iALL) undergo intense therapy to counter a highly aggressive malignancy with survival rates of only 30–40%. The majority of patients initially show therapy response, but in two-thirds of cases the leukemia returns, typically duri...

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Detalles Bibliográficos
Autores principales: Candelli, Tito, Schneider, Pauline, Garrido Castro, Patricia, Jones, Luke A., Bodewes, Eduard, Rockx-Brouwer, Dedeke, Pieters, Rob, Holstege, Frank C. P., Margaritis, Thanasis, Stam, Ronald W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727302/
https://www.ncbi.nlm.nih.gov/pubmed/34304246
http://dx.doi.org/10.1038/s41375-021-01341-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727302/
https://www.ncbi.nlm.nih.gov/pubmed/34304246
http://dx.doi.org/10.1038/s41375-021-01341-y

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