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Geographic Atrophy Progression Is Associated With Choriocapillaris Flow Deficits Measured With Optical Coherence Tomographic Angiography
PURPOSE: The purpose of this study was to assess the associations between baseline choriocapillaris (CC) flow deficits and geographic atrophy (GA) progression. METHODS: In this prospective cohort study, patients with GA underwent 3 × 3-mm macular spectral-domain optical coherence tomographic angiogr...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727307/ https://www.ncbi.nlm.nih.gov/pubmed/34964802 http://dx.doi.org/10.1167/iovs.62.15.28 |
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author | You, Qi Sheng Camino, Acner Wang, Jie Guo, Yukun Flaxel, Christina J. Hwang, Thomas S. Huang, David Jia, Yali Bailey, Steven T. |
author_facet | You, Qi Sheng Camino, Acner Wang, Jie Guo, Yukun Flaxel, Christina J. Hwang, Thomas S. Huang, David Jia, Yali Bailey, Steven T. |
author_sort | You, Qi Sheng |
collection | PubMed |
description | PURPOSE: The purpose of this study was to assess the associations between baseline choriocapillaris (CC) flow deficits and geographic atrophy (GA) progression. METHODS: In this prospective cohort study, patients with GA underwent 3 × 3-mm macular spectral-domain optical coherence tomographic angiography (OCTA) at baseline and follow-up visits. Annual GA enlargement rate was defined as change of square root of GA area in 12 months. Shadow areas due to iris, media opacity, retinal vessels, and drusen were excluded. CC vessel density (CC-VD) in non-GA areas was measured using a validated machine-learning-based algorithm. Low perfusion area (LPA) was defined as capillary density below the 0.1 percentile threshold of the same location of 40 normal healthy control eye. Focal perfusion loss (FPL) was defined as percentage of CC loss within LPA compared with normal controls. RESULTS: Ten patients with GA were enrolled and followed for 26 months on average. At baseline, the mean GA area was 0.84 ± 0.70 mm(2). The mean CC-VD was 44.5 ± 15.2%, the mean LPA was 4.29 ± 2.6 mm(2), and the mean FPL was 50.4 ± 28.2%. The annual GA enlargement rate was significantly associated with baseline CC-VD (r = −0.816, P = 0.004), LPA (r = 0.809, P = 0.005), and FPL (r = 0.800, P = 0.005), but not with age (r = 0.008, P = 0.98) and GA area (r = −0.362, P = 0.30). CONCLUSIONS: Baseline CC flow deficits were significantly associated with a faster GA enlargement over the course of 1 year, suggesting the choriocapillaris perfusion outside of a GA area may play a role in GA progression. |
format | Online Article Text |
id | pubmed-8727307 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Association for Research in Vision and Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-87273072022-01-14 Geographic Atrophy Progression Is Associated With Choriocapillaris Flow Deficits Measured With Optical Coherence Tomographic Angiography You, Qi Sheng Camino, Acner Wang, Jie Guo, Yukun Flaxel, Christina J. Hwang, Thomas S. Huang, David Jia, Yali Bailey, Steven T. Invest Ophthalmol Vis Sci Retina PURPOSE: The purpose of this study was to assess the associations between baseline choriocapillaris (CC) flow deficits and geographic atrophy (GA) progression. METHODS: In this prospective cohort study, patients with GA underwent 3 × 3-mm macular spectral-domain optical coherence tomographic angiography (OCTA) at baseline and follow-up visits. Annual GA enlargement rate was defined as change of square root of GA area in 12 months. Shadow areas due to iris, media opacity, retinal vessels, and drusen were excluded. CC vessel density (CC-VD) in non-GA areas was measured using a validated machine-learning-based algorithm. Low perfusion area (LPA) was defined as capillary density below the 0.1 percentile threshold of the same location of 40 normal healthy control eye. Focal perfusion loss (FPL) was defined as percentage of CC loss within LPA compared with normal controls. RESULTS: Ten patients with GA were enrolled and followed for 26 months on average. At baseline, the mean GA area was 0.84 ± 0.70 mm(2). The mean CC-VD was 44.5 ± 15.2%, the mean LPA was 4.29 ± 2.6 mm(2), and the mean FPL was 50.4 ± 28.2%. The annual GA enlargement rate was significantly associated with baseline CC-VD (r = −0.816, P = 0.004), LPA (r = 0.809, P = 0.005), and FPL (r = 0.800, P = 0.005), but not with age (r = 0.008, P = 0.98) and GA area (r = −0.362, P = 0.30). CONCLUSIONS: Baseline CC flow deficits were significantly associated with a faster GA enlargement over the course of 1 year, suggesting the choriocapillaris perfusion outside of a GA area may play a role in GA progression. The Association for Research in Vision and Ophthalmology 2021-12-29 /pmc/articles/PMC8727307/ /pubmed/34964802 http://dx.doi.org/10.1167/iovs.62.15.28 Text en Copyright 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
spellingShingle | Retina You, Qi Sheng Camino, Acner Wang, Jie Guo, Yukun Flaxel, Christina J. Hwang, Thomas S. Huang, David Jia, Yali Bailey, Steven T. Geographic Atrophy Progression Is Associated With Choriocapillaris Flow Deficits Measured With Optical Coherence Tomographic Angiography |
title | Geographic Atrophy Progression Is Associated With Choriocapillaris Flow Deficits Measured With Optical Coherence Tomographic Angiography |
title_full | Geographic Atrophy Progression Is Associated With Choriocapillaris Flow Deficits Measured With Optical Coherence Tomographic Angiography |
title_fullStr | Geographic Atrophy Progression Is Associated With Choriocapillaris Flow Deficits Measured With Optical Coherence Tomographic Angiography |
title_full_unstemmed | Geographic Atrophy Progression Is Associated With Choriocapillaris Flow Deficits Measured With Optical Coherence Tomographic Angiography |
title_short | Geographic Atrophy Progression Is Associated With Choriocapillaris Flow Deficits Measured With Optical Coherence Tomographic Angiography |
title_sort | geographic atrophy progression is associated with choriocapillaris flow deficits measured with optical coherence tomographic angiography |
topic | Retina |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727307/ https://www.ncbi.nlm.nih.gov/pubmed/34964802 http://dx.doi.org/10.1167/iovs.62.15.28 |
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