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Platelet-Tumor Cell Hybrid Membrane-Camouflaged Nanoparticles for Enhancing Therapy Efficacy in Glioma

PURPOSE: Cell membrane-camouflaged nanoparticles (NPs) are drawing increasing attention because their surfaces acquire some characteristics of the cell membranes, making them a unique class of biomimetic materials for diverse applications. Modification of cell membrane or combination of different ty...

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Autores principales: Wu, Lingling, Li, Qin, Deng, Junjie, Shen, Jinglan, Xu, Weide, Yang, Wei, Chen, Bingyu, Du, Yaoqiang, Zhang, Wei, Ge, Feihang, Lei, Siyun, Li, Kaiqiang, Wang, Zhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727453/
https://www.ncbi.nlm.nih.gov/pubmed/35002237
http://dx.doi.org/10.2147/IJN.S333279
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author Wu, Lingling
Li, Qin
Deng, Junjie
Shen, Jinglan
Xu, Weide
Yang, Wei
Chen, Bingyu
Du, Yaoqiang
Zhang, Wei
Ge, Feihang
Lei, Siyun
Li, Kaiqiang
Wang, Zhen
author_facet Wu, Lingling
Li, Qin
Deng, Junjie
Shen, Jinglan
Xu, Weide
Yang, Wei
Chen, Bingyu
Du, Yaoqiang
Zhang, Wei
Ge, Feihang
Lei, Siyun
Li, Kaiqiang
Wang, Zhen
author_sort Wu, Lingling
collection PubMed
description PURPOSE: Cell membrane-camouflaged nanoparticles (NPs) are drawing increasing attention because their surfaces acquire some characteristics of the cell membranes, making them a unique class of biomimetic materials for diverse applications. Modification of cell membrane or combination of different types of membranes can enhance their functionality. METHODS: We prepared platelet and tumor cell membrane camouflaged β-mangostin-loaded NPs, which were synthesized with platelet–C6 hybrid biomimetic coating, poly(lactic-co-glycolic acid), and β-mangostin (β-PCNPs). Then, we evaluated their targeting ability and anticancer activity against glioma in vitro and in vivo. RESULTS: Biomimetic coating enhanced active drug targeting and immune escape properties of nanocarrier in C6 and THP-1 cells, respectively, which improved their cytotoxicity. β-PCNPs were characterized to study the inherent properties of both source cells. Compared with bare β-NPs, β-PCNPs exhibited high tumor-targeting capability and induced apoptosis of C6 cells in vitro. Similarly, intravenous administration of drug through β-PCNPs resulted in enhanced tumor-targeting and exhibited excellent rate of inhibition of glioma tumor growth in mice. Moreover, the blood circulation time of drug in mice in the β-PCNP group was markedly prolonged and these mice exhibited better outcome than those in the β-NP group. CONCLUSION: These results provide a new strategy of utilizing PCNPs as carriers for drug delivery, which improves the targeting efficiency and therapeutic efficacy of chemotherapeutic agents for glioma therapy.
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spelling pubmed-87274532022-01-06 Platelet-Tumor Cell Hybrid Membrane-Camouflaged Nanoparticles for Enhancing Therapy Efficacy in Glioma Wu, Lingling Li, Qin Deng, Junjie Shen, Jinglan Xu, Weide Yang, Wei Chen, Bingyu Du, Yaoqiang Zhang, Wei Ge, Feihang Lei, Siyun Li, Kaiqiang Wang, Zhen Int J Nanomedicine Original Research PURPOSE: Cell membrane-camouflaged nanoparticles (NPs) are drawing increasing attention because their surfaces acquire some characteristics of the cell membranes, making them a unique class of biomimetic materials for diverse applications. Modification of cell membrane or combination of different types of membranes can enhance their functionality. METHODS: We prepared platelet and tumor cell membrane camouflaged β-mangostin-loaded NPs, which were synthesized with platelet–C6 hybrid biomimetic coating, poly(lactic-co-glycolic acid), and β-mangostin (β-PCNPs). Then, we evaluated their targeting ability and anticancer activity against glioma in vitro and in vivo. RESULTS: Biomimetic coating enhanced active drug targeting and immune escape properties of nanocarrier in C6 and THP-1 cells, respectively, which improved their cytotoxicity. β-PCNPs were characterized to study the inherent properties of both source cells. Compared with bare β-NPs, β-PCNPs exhibited high tumor-targeting capability and induced apoptosis of C6 cells in vitro. Similarly, intravenous administration of drug through β-PCNPs resulted in enhanced tumor-targeting and exhibited excellent rate of inhibition of glioma tumor growth in mice. Moreover, the blood circulation time of drug in mice in the β-PCNP group was markedly prolonged and these mice exhibited better outcome than those in the β-NP group. CONCLUSION: These results provide a new strategy of utilizing PCNPs as carriers for drug delivery, which improves the targeting efficiency and therapeutic efficacy of chemotherapeutic agents for glioma therapy. Dove 2021-12-29 /pmc/articles/PMC8727453/ /pubmed/35002237 http://dx.doi.org/10.2147/IJN.S333279 Text en © 2021 Wu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Wu, Lingling
Li, Qin
Deng, Junjie
Shen, Jinglan
Xu, Weide
Yang, Wei
Chen, Bingyu
Du, Yaoqiang
Zhang, Wei
Ge, Feihang
Lei, Siyun
Li, Kaiqiang
Wang, Zhen
Platelet-Tumor Cell Hybrid Membrane-Camouflaged Nanoparticles for Enhancing Therapy Efficacy in Glioma
title Platelet-Tumor Cell Hybrid Membrane-Camouflaged Nanoparticles for Enhancing Therapy Efficacy in Glioma
title_full Platelet-Tumor Cell Hybrid Membrane-Camouflaged Nanoparticles for Enhancing Therapy Efficacy in Glioma
title_fullStr Platelet-Tumor Cell Hybrid Membrane-Camouflaged Nanoparticles for Enhancing Therapy Efficacy in Glioma
title_full_unstemmed Platelet-Tumor Cell Hybrid Membrane-Camouflaged Nanoparticles for Enhancing Therapy Efficacy in Glioma
title_short Platelet-Tumor Cell Hybrid Membrane-Camouflaged Nanoparticles for Enhancing Therapy Efficacy in Glioma
title_sort platelet-tumor cell hybrid membrane-camouflaged nanoparticles for enhancing therapy efficacy in glioma
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727453/
https://www.ncbi.nlm.nih.gov/pubmed/35002237
http://dx.doi.org/10.2147/IJN.S333279
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