Hydrophilic Tetraphenylethene-Based Tetracationic Cyclophanes: NADPH Recognition and Cell Imaging With Fluorescent Switch

A hydrophilic TPE-based tetracationic cyclophane TPE-cyc was synthesized, which could capture intracellular Nicotinamide adenine dinucleotide phosphate and fuel the antioxidative ability of tumor cells to detoxify reactive oxygen species (ROS). Meanwhile, upon the reduction by cellular GSH, TPE-cyc...

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Detalles Bibliográficos
Autores principales: Wu, Dan, Zhang, Zhankui, Yu, Xinyang, Bai, Bing, Qi, Shaolong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727463/
https://www.ncbi.nlm.nih.gov/pubmed/35004632
http://dx.doi.org/10.3389/fchem.2021.817720
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author Wu, Dan
Zhang, Zhankui
Yu, Xinyang
Bai, Bing
Qi, Shaolong
author_facet Wu, Dan
Zhang, Zhankui
Yu, Xinyang
Bai, Bing
Qi, Shaolong
author_sort Wu, Dan
collection PubMed
description A hydrophilic TPE-based tetracationic cyclophane TPE-cyc was synthesized, which could capture intracellular Nicotinamide adenine dinucleotide phosphate and fuel the antioxidative ability of tumor cells to detoxify reactive oxygen species (ROS). Meanwhile, upon the reduction by cellular GSH, TPE-cyc could light up tumor cells, acting as a GSH-responsive fluorescent switch to image cells with high resolution.
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spelling pubmed-87274632022-01-06 Hydrophilic Tetraphenylethene-Based Tetracationic Cyclophanes: NADPH Recognition and Cell Imaging With Fluorescent Switch Wu, Dan Zhang, Zhankui Yu, Xinyang Bai, Bing Qi, Shaolong Front Chem Chemistry A hydrophilic TPE-based tetracationic cyclophane TPE-cyc was synthesized, which could capture intracellular Nicotinamide adenine dinucleotide phosphate and fuel the antioxidative ability of tumor cells to detoxify reactive oxygen species (ROS). Meanwhile, upon the reduction by cellular GSH, TPE-cyc could light up tumor cells, acting as a GSH-responsive fluorescent switch to image cells with high resolution. Frontiers Media S.A. 2021-12-22 /pmc/articles/PMC8727463/ /pubmed/35004632 http://dx.doi.org/10.3389/fchem.2021.817720 Text en Copyright © 2021 Wu, Zhang, Yu, Bai and Qi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Wu, Dan
Zhang, Zhankui
Yu, Xinyang
Bai, Bing
Qi, Shaolong
Hydrophilic Tetraphenylethene-Based Tetracationic Cyclophanes: NADPH Recognition and Cell Imaging With Fluorescent Switch
title Hydrophilic Tetraphenylethene-Based Tetracationic Cyclophanes: NADPH Recognition and Cell Imaging With Fluorescent Switch
title_full Hydrophilic Tetraphenylethene-Based Tetracationic Cyclophanes: NADPH Recognition and Cell Imaging With Fluorescent Switch
title_fullStr Hydrophilic Tetraphenylethene-Based Tetracationic Cyclophanes: NADPH Recognition and Cell Imaging With Fluorescent Switch
title_full_unstemmed Hydrophilic Tetraphenylethene-Based Tetracationic Cyclophanes: NADPH Recognition and Cell Imaging With Fluorescent Switch
title_short Hydrophilic Tetraphenylethene-Based Tetracationic Cyclophanes: NADPH Recognition and Cell Imaging With Fluorescent Switch
title_sort hydrophilic tetraphenylethene-based tetracationic cyclophanes: nadph recognition and cell imaging with fluorescent switch
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727463/
https://www.ncbi.nlm.nih.gov/pubmed/35004632
http://dx.doi.org/10.3389/fchem.2021.817720
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