Topical Ketotifen Fumarate Inhibits Choroidal Mast Cell Degranulation and Loss of Retinal Pigment Epithelial Cells in Rat Model for Geographic Atrophy

PURPOSE: This study evaluates whether topical ketotifen fumarate (KTF) can prevent geographic atrophy (GA)-like phenotypes in a rat model. METHODS: Pharmacokinetics (PKs) of KTF after topical administration twice daily for 5 days was analyzed in rat retina, retinal pigment epithelium (RPE)/choroid/s...

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Detalles Bibliográficos
Autores principales: Nizawa, Tomohiro, Bhutto, Imran A., Tiwari, Anupama, Grebe, Rhonda R., Alt, Jesse, Rais, Rana, Edwards, Malia M., Lutty, Gerard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727493/
https://www.ncbi.nlm.nih.gov/pubmed/34967831
http://dx.doi.org/10.1167/tvst.10.14.37

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727493/
https://www.ncbi.nlm.nih.gov/pubmed/34967831
http://dx.doi.org/10.1167/tvst.10.14.37

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