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A stem cell marker KLF5 regulates CCAT1 via three-dimensional genome structure in colorectal cancer cells

BACKGROUND: KLF5 plays a crucial role in stem cells of colorectum in cooperation with Lgr5 gene. In this study, we aimed to explicate a regulatory mechanism of the KLF5 gene product from a view of three-dimensional genome structure in colorectal cancer (CRC). METHODS: In vitro engineered DNA-binding...

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Detalles Bibliográficos
Autores principales:	Takeda, Takashi, Yokoyama, Yuhki, Takahashi, Hidekazu, Okuzaki, Daisuke, Asai, Kaho, Itakura, Hiroaki, Miyoshi, Norikatsu, Kobayashi, Shogo, Uemura, Mamoru, Fujita, Toshitsugu, Ueno, Hiroo, Mori, Masaki, Doki, Yuichiro, Fujii, Hodaka, Eguchi, Hidetoshi, Yamamoto, Hirofumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727571/ https://www.ncbi.nlm.nih.gov/pubmed/34707247 http://dx.doi.org/10.1038/s41416-021-01579-4

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