Functional assessment of somatic STK11 variants identified in primary human non-small cell lung cancers

Serine/Threonine Kinase 11 (STK11) encodes an important tumor suppressor that is frequently mutated in lung adenocarcinoma. Clinical studies have shown that mutations in STK11 resulting in loss of function correlate with resistance to anti-PD-1 monoclonal antibody therapy in KRAS-driven non-small ce...

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Detalles Bibliográficos
Autores principales: Donnelly, Liam L, Hogan, Tyler C, Lenahan, Sean M, Nandagopal, Gopika, Eaton, Jenna G, Lebeau, Meagan A, McCann, Cai L, Sarausky, Hailey M, Hampel, Kenneth J, Armstrong, Jordan D, Cameron, Margaret P, Sidiropoulos, Nikoletta, Deming, Paula, Seward, David J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Cancer Biomarkers and Molecular Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727739/
https://www.ncbi.nlm.nih.gov/pubmed/34849607
http://dx.doi.org/10.1093/carcin/bgab104

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