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m(6)A Regulator Expression Segregates Meningiomas Into Biologically Distinct Subtypes
BACKGROUND: Meningiomas are the most common primary intracranial tumors in adults. According to the 2021 World Health Organization (WHO) classification of central nervous system tumors, approximately 80% of meningiomas are WHO grade 1, that is, histopathologically benign, whereas about 20% are WHO g...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727752/ https://www.ncbi.nlm.nih.gov/pubmed/35004283 http://dx.doi.org/10.3389/fonc.2021.760892 |
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author | Chen, Jiawei Sun, Shuchen Ren, Leihao Hua, Lingyang Wang, Daijun Xie, Qing Wirsching, Hans-Georg Deng, Jiaojiao Weller, Michael Gong, Ye |
author_facet | Chen, Jiawei Sun, Shuchen Ren, Leihao Hua, Lingyang Wang, Daijun Xie, Qing Wirsching, Hans-Georg Deng, Jiaojiao Weller, Michael Gong, Ye |
author_sort | Chen, Jiawei |
collection | PubMed |
description | BACKGROUND: Meningiomas are the most common primary intracranial tumors in adults. According to the 2021 World Health Organization (WHO) classification of central nervous system tumors, approximately 80% of meningiomas are WHO grade 1, that is, histopathologically benign, whereas about 20% are WHO grade 2 or grade 3, showing signs of atypia or malignancy. The dysregulation of N6-methylation (m(6)A) regulators is associated with disorders of diverse critical biological processes in human cancer. This study aimed to explore whether m(6)A regulator expression was associated with meningioma molecular subtypes and immune infiltration. METHODS: We evaluated the m(6)A modification patterns of 160 meningioma samples based on 19 m(6)A regulators and correlated them with immune infiltration characteristics. Novel molecular subtypes were defined based on prognostic hub gene expression. RESULTS: Two meningioma clusters were identified based on the expression of 19 m(6)A regulators. In cluster 1, 607 differentially expressed genes (DEGs) were upregulated and 519 were downregulated. A total of 1,126 DEGs comprised three gene expression modules characterized by turquoise, blue, and gray. Functional annotation suggested that the turquoise module was involved in Wnt-related and other important cancer-related pathways. We identified 32 hub genes in this module by constructing a protein–protein interaction network. The meningioma samples were divided into two molecular subtypes. EPN1, EXOSC4, H2AX, and MZT2B not only showed significant differences between meningioma molecular subtypes but also had the potential to be the marker genes of specific meningioma subtypes. CONCLUSION: m(6)A regulator gene expression may be a novel prognostic marker in meningioma. |
format | Online Article Text |
id | pubmed-8727752 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87277522022-01-06 m(6)A Regulator Expression Segregates Meningiomas Into Biologically Distinct Subtypes Chen, Jiawei Sun, Shuchen Ren, Leihao Hua, Lingyang Wang, Daijun Xie, Qing Wirsching, Hans-Georg Deng, Jiaojiao Weller, Michael Gong, Ye Front Oncol Oncology BACKGROUND: Meningiomas are the most common primary intracranial tumors in adults. According to the 2021 World Health Organization (WHO) classification of central nervous system tumors, approximately 80% of meningiomas are WHO grade 1, that is, histopathologically benign, whereas about 20% are WHO grade 2 or grade 3, showing signs of atypia or malignancy. The dysregulation of N6-methylation (m(6)A) regulators is associated with disorders of diverse critical biological processes in human cancer. This study aimed to explore whether m(6)A regulator expression was associated with meningioma molecular subtypes and immune infiltration. METHODS: We evaluated the m(6)A modification patterns of 160 meningioma samples based on 19 m(6)A regulators and correlated them with immune infiltration characteristics. Novel molecular subtypes were defined based on prognostic hub gene expression. RESULTS: Two meningioma clusters were identified based on the expression of 19 m(6)A regulators. In cluster 1, 607 differentially expressed genes (DEGs) were upregulated and 519 were downregulated. A total of 1,126 DEGs comprised three gene expression modules characterized by turquoise, blue, and gray. Functional annotation suggested that the turquoise module was involved in Wnt-related and other important cancer-related pathways. We identified 32 hub genes in this module by constructing a protein–protein interaction network. The meningioma samples were divided into two molecular subtypes. EPN1, EXOSC4, H2AX, and MZT2B not only showed significant differences between meningioma molecular subtypes but also had the potential to be the marker genes of specific meningioma subtypes. CONCLUSION: m(6)A regulator gene expression may be a novel prognostic marker in meningioma. Frontiers Media S.A. 2021-12-22 /pmc/articles/PMC8727752/ /pubmed/35004283 http://dx.doi.org/10.3389/fonc.2021.760892 Text en Copyright © 2021 Chen, Sun, Ren, Hua, Wang, Xie, Wirsching, Deng, Weller and Gong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Chen, Jiawei Sun, Shuchen Ren, Leihao Hua, Lingyang Wang, Daijun Xie, Qing Wirsching, Hans-Georg Deng, Jiaojiao Weller, Michael Gong, Ye m(6)A Regulator Expression Segregates Meningiomas Into Biologically Distinct Subtypes |
title | m(6)A Regulator Expression Segregates Meningiomas Into Biologically Distinct Subtypes |
title_full | m(6)A Regulator Expression Segregates Meningiomas Into Biologically Distinct Subtypes |
title_fullStr | m(6)A Regulator Expression Segregates Meningiomas Into Biologically Distinct Subtypes |
title_full_unstemmed | m(6)A Regulator Expression Segregates Meningiomas Into Biologically Distinct Subtypes |
title_short | m(6)A Regulator Expression Segregates Meningiomas Into Biologically Distinct Subtypes |
title_sort | m(6)a regulator expression segregates meningiomas into biologically distinct subtypes |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727752/ https://www.ncbi.nlm.nih.gov/pubmed/35004283 http://dx.doi.org/10.3389/fonc.2021.760892 |
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