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A small molecule UPR modulator for diabetes identified by high throughput screening

Unfolded protein response (UPR) is a stress response that is specific to the endoplasmic reticulum (ER). UPR is activated upon accumulation of unfolded (or misfolded) proteins in the ER's lumen to restore protein folding capacity by increasing the synthesis of chaperones. In addition, UPR also...

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Detalles Bibliográficos
Autores principales:	Marrocco, Valeria, Tran, Tuan, Zhu, Siying, Choi, Seung Hyuk, Gamo, Ana M., Li, Sijia, Fu, Qiangwei, Cunado, Marta Diez, Roland, Jason, Hull, Mitch, Nguyen-Tran, Van, Joseph, Sean, Chatterjee, Arnab K., Rogers, Nikki, Tremblay, Matthew S., Shen, Weijun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727761/ https://www.ncbi.nlm.nih.gov/pubmed/35024320 http://dx.doi.org/10.1016/j.apsb.2021.05.018

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