Target-responsive subcellular catabolism analysis for early-stage antibody–drug conjugates screening and assessment

Events including antibody‒antigen affinity, internalization, trafficking and lysosomal proteolysis combinatorially determine the efficiency of antibody–drug conjugate (ADC) catabolism and hence the toxicity. Nevertheless, an approach that conveniently identifies proteins requisite for payload releas...

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Detalles Bibliográficos
Autores principales: Sang, Hua, Liu, Jiali, Zhou, Fang, Zhang, Xiaofang, Zhang, Jingwei, Liu, Yazhong, Wang, Guangji, Ye, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727762/
https://www.ncbi.nlm.nih.gov/pubmed/35024323
http://dx.doi.org/10.1016/j.apsb.2021.05.024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727762/
https://www.ncbi.nlm.nih.gov/pubmed/35024323
http://dx.doi.org/10.1016/j.apsb.2021.05.024

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