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Differences in Regression Patterns of Complete and Incomplete Intestinal Metaplasia at Ten Years after Helicobacter pylori Eradication

This study was conducted to reveal the reversibility of subtype of intestinal metaplasia (IM) and Paneth cells after H. pylori eradication (HPE). Among 75 patients, we retrospectively examined the proportions of patients with complete type of IM (CIM), incomplete type of IM (IIM) and Paneth cells in...

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Autores principales: Wada, Yasuhiro, Kodama, Masaaki, Mizukami, Kazuhiro, Okimoto, Tadayoshi, Fuchino, Takafumi, Tsutsumi, Koshiro, Fukuda, Masahide, Hirashita, Yuka, Fukuda, Kensuke, Okamoto, Kazuhisa, Ogawa, Ryo, Kushima, Ryoji, Murakami, Kazunari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727845/
https://www.ncbi.nlm.nih.gov/pubmed/35023881
http://dx.doi.org/10.1267/ahc.21-00069
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author Wada, Yasuhiro
Kodama, Masaaki
Mizukami, Kazuhiro
Okimoto, Tadayoshi
Fuchino, Takafumi
Tsutsumi, Koshiro
Fukuda, Masahide
Hirashita, Yuka
Fukuda, Kensuke
Okamoto, Kazuhisa
Ogawa, Ryo
Kushima, Ryoji
Murakami, Kazunari
author_facet Wada, Yasuhiro
Kodama, Masaaki
Mizukami, Kazuhiro
Okimoto, Tadayoshi
Fuchino, Takafumi
Tsutsumi, Koshiro
Fukuda, Masahide
Hirashita, Yuka
Fukuda, Kensuke
Okamoto, Kazuhisa
Ogawa, Ryo
Kushima, Ryoji
Murakami, Kazunari
author_sort Wada, Yasuhiro
collection PubMed
description This study was conducted to reveal the reversibility of subtype of intestinal metaplasia (IM) and Paneth cells after H. pylori eradication (HPE). Among 75 patients, we retrospectively examined the proportions of patients with complete type of IM (CIM), incomplete type of IM (IIM) and Paneth cells in their biopsy specimens obtained from the greater curvature of the antrum (A2) and the greater curvature of the middle corpus (B2) before and during a follow-up period of 10 years after HPE. Immunohistochemistry was used to determine IM type. Compared to before HPE, the proportion of patients with CIM did not decrease significantly during the 10-year follow-up after HPE both in A2 (32% vs. 21.3%, P = 0.13) and in B2 (6.7% vs. 2.7%, P = 0.60). IIM rates in A2 was significantly lower during this time (26.7% vs. 10.7%, P = 0.04), whereas no patients showed IIM in B2 before HPE. The proportion of patients with Paneth cells decreased significantly in A2 after 3, 8, and 9 years of HPE and in B2 after 4, 6 and 9 years of HPE (P < 0.05 for all). Thus, IIM and Paneth cells regressed during a period of 10 years after HPE.
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spelling pubmed-87278452022-01-11 Differences in Regression Patterns of Complete and Incomplete Intestinal Metaplasia at Ten Years after Helicobacter pylori Eradication Wada, Yasuhiro Kodama, Masaaki Mizukami, Kazuhiro Okimoto, Tadayoshi Fuchino, Takafumi Tsutsumi, Koshiro Fukuda, Masahide Hirashita, Yuka Fukuda, Kensuke Okamoto, Kazuhisa Ogawa, Ryo Kushima, Ryoji Murakami, Kazunari Acta Histochem Cytochem Regular Article This study was conducted to reveal the reversibility of subtype of intestinal metaplasia (IM) and Paneth cells after H. pylori eradication (HPE). Among 75 patients, we retrospectively examined the proportions of patients with complete type of IM (CIM), incomplete type of IM (IIM) and Paneth cells in their biopsy specimens obtained from the greater curvature of the antrum (A2) and the greater curvature of the middle corpus (B2) before and during a follow-up period of 10 years after HPE. Immunohistochemistry was used to determine IM type. Compared to before HPE, the proportion of patients with CIM did not decrease significantly during the 10-year follow-up after HPE both in A2 (32% vs. 21.3%, P = 0.13) and in B2 (6.7% vs. 2.7%, P = 0.60). IIM rates in A2 was significantly lower during this time (26.7% vs. 10.7%, P = 0.04), whereas no patients showed IIM in B2 before HPE. The proportion of patients with Paneth cells decreased significantly in A2 after 3, 8, and 9 years of HPE and in B2 after 4, 6 and 9 years of HPE (P < 0.05 for all). Thus, IIM and Paneth cells regressed during a period of 10 years after HPE. JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY 2021-12-24 2021-11-18 /pmc/articles/PMC8727845/ /pubmed/35023881 http://dx.doi.org/10.1267/ahc.21-00069 Text en 2021 The Japan Society of Histochemistry and Cytochemistry https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the Creative Commons License (CC-BY-NC), which permits use, distribution and reproduction of the articles in any medium provided that the original work is properly cited and is not used for commercial purposes.
spellingShingle Regular Article
Wada, Yasuhiro
Kodama, Masaaki
Mizukami, Kazuhiro
Okimoto, Tadayoshi
Fuchino, Takafumi
Tsutsumi, Koshiro
Fukuda, Masahide
Hirashita, Yuka
Fukuda, Kensuke
Okamoto, Kazuhisa
Ogawa, Ryo
Kushima, Ryoji
Murakami, Kazunari
Differences in Regression Patterns of Complete and Incomplete Intestinal Metaplasia at Ten Years after Helicobacter pylori Eradication
title Differences in Regression Patterns of Complete and Incomplete Intestinal Metaplasia at Ten Years after Helicobacter pylori Eradication
title_full Differences in Regression Patterns of Complete and Incomplete Intestinal Metaplasia at Ten Years after Helicobacter pylori Eradication
title_fullStr Differences in Regression Patterns of Complete and Incomplete Intestinal Metaplasia at Ten Years after Helicobacter pylori Eradication
title_full_unstemmed Differences in Regression Patterns of Complete and Incomplete Intestinal Metaplasia at Ten Years after Helicobacter pylori Eradication
title_short Differences in Regression Patterns of Complete and Incomplete Intestinal Metaplasia at Ten Years after Helicobacter pylori Eradication
title_sort differences in regression patterns of complete and incomplete intestinal metaplasia at ten years after helicobacter pylori eradication
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727845/
https://www.ncbi.nlm.nih.gov/pubmed/35023881
http://dx.doi.org/10.1267/ahc.21-00069
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