Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity

Disease-mediated alterations to drug disposition constitute a significant source of adverse drug reactions. Cisplatin (CDDP) elicits nephrotoxicity due to exposure in proximal tubule cells during renal secretion. Alterations to renal drug transporter expression have been discovered during nonalcohol...

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Detalles Bibliográficos
Autores principales: Jilek, Joseph L., Frost, Kayla L., Jacobus, Kevyn A., He, Wenxi, Toth, Erica L., Goedken, Michael, Cherrington, Nathan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727892/
https://www.ncbi.nlm.nih.gov/pubmed/35024313
http://dx.doi.org/10.1016/j.apsb.2021.05.030

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