Cargando…
Galleria mellonella as a Suitable Model of Bacterial Infection: Past, Present and Future
The increasing interest for Galleria mellonella larvae as an infection model is evidenced by the number of papers reporting its use, which increases exponentially since the early 2010s. This popularity was initially linked to limitation of conventional animal models due to financial, technical and e...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727906/ https://www.ncbi.nlm.nih.gov/pubmed/35004350 http://dx.doi.org/10.3389/fcimb.2021.782733 |
_version_ | 1784626611097698304 |
---|---|
author | Ménard, Guillaume Rouillon, Astrid Cattoir, Vincent Donnio, Pierre-Yves |
author_facet | Ménard, Guillaume Rouillon, Astrid Cattoir, Vincent Donnio, Pierre-Yves |
author_sort | Ménard, Guillaume |
collection | PubMed |
description | The increasing interest for Galleria mellonella larvae as an infection model is evidenced by the number of papers reporting its use, which increases exponentially since the early 2010s. This popularity was initially linked to limitation of conventional animal models due to financial, technical and ethical aspects. In comparison, alternative models (e.g. models using Caenorhabditis elegans, Drosophila melanogaster or G. mellonella) were cheap, simple to use and not limited by ethical regulation. Since then, similar results have been established with G. mellonella model comparatively to vertebrates, and it is more and more often used as a robust model per se, not only as an alternative to the murine model. This review attempts to summarize the current knowledge supporting the development of this model, both on immunological and microbiological aspects. For that, we focus on investigation of virulence and new therapies for the most important pathogenic bacteria. We also discuss points out directions for standardization, as well as recent advances and new perspectives for monitoring host-pathogen interactions. |
format | Online Article Text |
id | pubmed-8727906 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87279062022-01-06 Galleria mellonella as a Suitable Model of Bacterial Infection: Past, Present and Future Ménard, Guillaume Rouillon, Astrid Cattoir, Vincent Donnio, Pierre-Yves Front Cell Infect Microbiol Cellular and Infection Microbiology The increasing interest for Galleria mellonella larvae as an infection model is evidenced by the number of papers reporting its use, which increases exponentially since the early 2010s. This popularity was initially linked to limitation of conventional animal models due to financial, technical and ethical aspects. In comparison, alternative models (e.g. models using Caenorhabditis elegans, Drosophila melanogaster or G. mellonella) were cheap, simple to use and not limited by ethical regulation. Since then, similar results have been established with G. mellonella model comparatively to vertebrates, and it is more and more often used as a robust model per se, not only as an alternative to the murine model. This review attempts to summarize the current knowledge supporting the development of this model, both on immunological and microbiological aspects. For that, we focus on investigation of virulence and new therapies for the most important pathogenic bacteria. We also discuss points out directions for standardization, as well as recent advances and new perspectives for monitoring host-pathogen interactions. Frontiers Media S.A. 2021-12-22 /pmc/articles/PMC8727906/ /pubmed/35004350 http://dx.doi.org/10.3389/fcimb.2021.782733 Text en Copyright © 2021 Ménard, Rouillon, Cattoir and Donnio https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Ménard, Guillaume Rouillon, Astrid Cattoir, Vincent Donnio, Pierre-Yves Galleria mellonella as a Suitable Model of Bacterial Infection: Past, Present and Future |
title |
Galleria mellonella as a Suitable Model of Bacterial Infection: Past, Present and Future |
title_full |
Galleria mellonella as a Suitable Model of Bacterial Infection: Past, Present and Future |
title_fullStr |
Galleria mellonella as a Suitable Model of Bacterial Infection: Past, Present and Future |
title_full_unstemmed |
Galleria mellonella as a Suitable Model of Bacterial Infection: Past, Present and Future |
title_short |
Galleria mellonella as a Suitable Model of Bacterial Infection: Past, Present and Future |
title_sort | galleria mellonella as a suitable model of bacterial infection: past, present and future |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727906/ https://www.ncbi.nlm.nih.gov/pubmed/35004350 http://dx.doi.org/10.3389/fcimb.2021.782733 |
work_keys_str_mv | AT menardguillaume galleriamellonellaasasuitablemodelofbacterialinfectionpastpresentandfuture AT rouillonastrid galleriamellonellaasasuitablemodelofbacterialinfectionpastpresentandfuture AT cattoirvincent galleriamellonellaasasuitablemodelofbacterialinfectionpastpresentandfuture AT donniopierreyves galleriamellonellaasasuitablemodelofbacterialinfectionpastpresentandfuture |