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Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice

PEGylated-l-asparaginase (PEG-ASNase) is a chemotherapeutic agent used to treat pediatric acute lymphoblastic leukemia (ALL). Its use is avoided in adults due to its high risk of liver injury including hepatic steatosis, with obesity and older age considered risk factors of the injury. Our study aim...

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Detalles Bibliográficos
Autores principales:	Kumar, Gundala Venkata Naveen, Hoshitsuki, Keito, Rathod, Sanjay, Ramsey, Manda J., Kokai, Lauren, Kershaw, Erin E., Xie, Wen, Fernandez, Christian A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727916/ https://www.ncbi.nlm.nih.gov/pubmed/35024306 http://dx.doi.org/10.1016/j.apsb.2021.11.022

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