Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls

Acetaminophen (APAP) is a widely used analgesic and antipyretic drug, which is safe at therapeutic doses but can cause severe liver injury and even liver failure after overdoses. The mouse model of APAP hepatotoxicity recapitulates closely the human pathophysiology. As a result, this clinically rele...

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Detalles Bibliográficos
Autores principales: Jaeschke, Hartmut, Adelusi, Olamide B., Akakpo, Jephte Y., Nguyen, Nga T., Sanchez-Guerrero, Giselle, Umbaugh, David S., Ding, Wen-Xing, Ramachandran, Anup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727921/
https://www.ncbi.nlm.nih.gov/pubmed/35024303
http://dx.doi.org/10.1016/j.apsb.2021.09.023

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