Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk

We previously demonstrated that endogenous phosphatidic acid (PA) promotes liver regeneration after acetaminophen (APAP) hepatotoxicity. Here, we hypothesized that exogenous PA is also beneficial. To test that, we treated mice with a toxic APAP dose at 0 h, followed by PA or vehicle (Veh) post-treat...

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Detalles Bibliográficos
Autores principales: Clemens, Melissa M., Kennon-McGill, Stefanie, Vazquez, Joel H., Stephens, Owen W., Peterson, Erich A., Johann, Donald J., Allard, Felicia D., Yee, Eric U., McCullough, Sandra S., James, Laura P., Finck, Brian N., McGill, Mitchell R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727922/
https://www.ncbi.nlm.nih.gov/pubmed/35024310
http://dx.doi.org/10.1016/j.apsb.2021.08.024

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