Cargando…

P2X(2) receptors supply extracellular choline as a substrate for acetylcholine synthesis

Acetylcholine (ACh), an excitatory neurotransmitter, is biosynthesized from choline in cholinergic neurons. Import from the extracellular space to the intracellular environment through the high‐affinity choline transporter is currently regarded to be the only source of choline for ACh synthesis. We...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maruyama, Takuma, Mano, Asuka, Ishii, Toshiyuki, Kakinuma, Yoshihiko, Kaneda, Makoto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727932/ https://www.ncbi.nlm.nih.gov/pubmed/34787962 http://dx.doi.org/10.1002/2211-5463.13332

Ejemplares similares

Starburst amacrine cells form gap junctions in the early postnatal stage of the mouse retina
por: Maruyama, Takuma, et al.
Publicado: (2023)

Generation of choline for acetylcholine synthesis by phospholipase D isoforms
por: Zhao, Di, et al.
Publicado: (2001)

Characteristic Effects of the Cardiac Non-Neuronal Acetylcholine System Augmentation on Brain Functions
por: Kakinuma, Yoshihiko
Publicado: (2021)

Mutant SOD1 impairs axonal transport of choline acetyltransferase and acetylcholine release by sequestering KAP3
por: Tateno, Minako, et al.
Publicado: (2009)

Regulated Extracellular Choline Acetyltransferase Activity— The Plausible Missing Link of the Distant Action of Acetylcholine in the Cholinergic Anti-Inflammatory Pathway
por: Vijayaraghavan, Swetha, et al.
Publicado: (2013)

Gold nanoparticle–choline complexes can block nicotinic acetylcholine receptors
por: Chin, Chur, et al.
Publicado: (2010)

The Mechanism of Choline-Mediated Inhibition of Acetylcholine Release in Mouse Motor Synapses
por: Gaydukov, A. E., et al.
Publicado: (2014)

Mechanisms controlling choline transport and acetylcholine synthesis in motor nerve terminals during electrical stimulation
Publicado: (1979)

Fluorescent Molecular Cages with Sucrose and Cyclotriveratrylene Units for the Selective Recognition of Choline and Acetylcholine
por: Szyszka, Łukasz, et al.
Publicado: (2021)

Expression of choline and acetylcholine transporters in synovial tissue and cartilage of patients with rheumatoid arthritis and osteoarthritis
por: Beckmann, Janet, et al.
Publicado: (2014)

CaMKII Is Involved in the Choline-Induced Downregulation of Acetylcholine Release in Mouse Motor Synapses
por: Gaydukov, A. E., et al.
Publicado: (2017)

Direct Electrochemical Detection of Glutamate, Acetylcholine, Choline, and Adenosine Using Non-Enzymatic Electrodes
por: Shadlaghani, Arash, et al.
Publicado: (2019)

Metabolism of acetylcholine in the nervous system of Aplysia californica. II. Reginal localization and characterization of choline uptake
Publicado: (1975)

Heart‐Specific Overexpression of Choline Acetyltransferase Gene Protects Murine Heart Against Ischemia Through Hypoxia‐Inducible Factor‐1α–Related Defense Mechanisms
por: Kakinuma, Yoshihiko, et al.
Publicado: (2013)

Metabolism of acetylcholine in the nervous system of Aplysia californica. I. Source of choline and its uptake by intact nervous tissue
Publicado: (1975)

Loss of Choline Agonism in the Inner Ear Hair Cell Nicotinic Acetylcholine Receptor Linked to the α10 Subunit
por: Moglie, Marcelo J., et al.
Publicado: (2021)

Gating Dynamics of the Acetylcholine Receptor Extracellular Domain
por: Chakrapani, Sudha, et al.
Publicado: (2004)

Choline Attenuates Cardiac Fibrosis by Inhibiting p38MAPK Signaling Possibly by Acting on M(3) Muscarinic Acetylcholine Receptor
por: Zhao, Lihui, et al.
Publicado: (2019)

Acetylcholine Receptor Gating: Movement in the α-Subunit Extracellular Domain
por: Purohit, Prasad, et al.
Publicado: (2007)

Cell-free Production of the Extracellular Domain of the Nicotinic Acetylcholine Receptor
por: Lyukmanova, E.N., et al.
Publicado: (2009)

Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors
por: Jakubík, Jan, et al.
Publicado: (2017)

Vibrational spectroscopy analysis of ligand efficacy in human M(2) muscarinic acetylcholine receptor (M(2)R)
por: Katayama, Kota, et al.
Publicado: (2021)

Impact of Different Oxygen Supply Methods on the Healing of Corneal Epithelial Wound and the Level of Acetylcholine
por: Li, Shanshan, et al.
Publicado: (2021)

THE MECHANISM OF ENZYME-INHIBITOR-SUBSTRATE REACTIONS : ILLUSTRATED BY THE CHOLINESTERASE-PHYSOSTIGMINE-ACETYLCHOLINE SYSTEM
por: Goldstein, Avram
Publicado: (1944)

Neuronal Nicotinic Acetylcholine Receptors: Common Molecular Substrates of Nicotine and Alcohol Dependence
por: Hendrickson, Linzy M., et al.
Publicado: (2013)

Optimisation of [(11)C]-choline synthesis
por: Szydło, Marcin, et al.
Publicado: (2018)

Analysis of oxidative stress and antioxidative potential in premature ovarian insufficiency
por: Kakinuma, Kaoru, et al.
Publicado: (2023)

Extracellular matrix organization in developing muscle: correlation with acetylcholine receptor aggregates
Publicado: (1984)

Acetylcholine Receptor Gating at Extracellular Transmembrane Domain Interface: the Cys-Loop and M2–M3 Linker
por: Jha, Archana, et al.
Publicado: (2007)

Effectiveness of treating menorrhagia using microwave endometrial ablation at a frequency of 2.45 GHz
por: Kakinuma, Toshiyuki, et al.
Publicado: (2023)

CHOLINE AS A MEMBER OF THE VITAMIN B(2) COMPLEX
por: György, Paul, et al.
Publicado: (1940)

Derivation of human differential photoreceptor cells from adult human dermal fibroblasts by defined combinations of CRX, RAX, OTX2 and NEUROD
por: Seko, Yuko, et al.
Publicado: (2014)

Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP(3)-Evoked Ca(2+) Signals through Sigma-1 Receptors
por: Brailoiu, Eugen, et al.
Publicado: (2019)

Asymmetric and Independent Contribution of the Second Transmembrane Segment 12′ Residues to Diliganded Gating of Acetylcholine Receptor Channels: A Single-Channel Study with Choline as the Agonist
por: Grosman, Claudio, et al.
Publicado: (2000)

Synthesis, isolation and purification of [(11)C]-choline
por: Szydło, Marcin, et al.
Publicado: (2016)

Bioprocess design guided by in situ substrate supply and product removal: Process intensification for synthesis of (S)-1-(2-chlorophenyl)ethanol
por: Schmölzer, Katharina, et al.
Publicado: (2012)

Adipose stem cells enhance myoblast proliferation via acetylcholine and extracellular signal–regulated kinase 1/2 signaling
por: El‐Habta, Roine, et al.
Publicado: (2017)

Extracellular binding of indinavir to matrix metalloproteinase-2 and the alpha-7-nicotinic acetylcholine receptor: implications for use in cancer treatment
por: Lee, Anna, et al.
Publicado: (2019)

The Extracellular Linker of Muscle Acetylcholine Receptor Channels Is a Gating Control Element
por: Grosman, Claudio, et al.
Publicado: (2000)

Extracellular synaptic factors induce clustering of acetylcholine receptors stably expressed in fibroblasts
Publicado: (1991)

Cannot write session to /tmp/vufind_sessions/sess_mt1ofc3m3u9go5pd8p1esdkquu