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Exploring the Two Coupled Conformational Changes That Activate the Munc18-1/Syntaxin-1 Complex

Calcium-dependent synaptic vesicle exocytosis is mediated by SNARE complex formation. The transition from the Munc18-1/syntaxin-1 complex to the SNARE complex is catalyzed by the Munc13-1 MUN domain and involves at least two conformational changes: opening of the syntaxin-1 linker region and extensi...

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Detalles Bibliográficos
Autores principales:	Gong, Jihong, Wang, Xianping, Cui, Chaoyang, Qin, Yuyang, Jin, Ziqi, Ma, Cong, Yang, Xiaofei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728020/ https://www.ncbi.nlm.nih.gov/pubmed/35002621 http://dx.doi.org/10.3389/fnmol.2021.785696

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