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Evaluation of Bone Marrow Texture and Trabecular Changes With Quantitative DCE-MRI and QCT in Alloxan-Induced Diabetic Rabbit Models

PURPOSE: To investigate whether the microvascular permeability of lumbar marrow and bone trabecular changes in early-stage diabetic rabbits can be quantitatively evaluated using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), quantitative computed tomography, and texture-analyzed per...

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Autores principales: Chen, Pianpian, Zha, Yunfei, Wang, Li, Li, Liang, Hu, Lei, Xing, Dong, Liu, Baiyu, Yang, Liu, Yang, Qi, Liu, Changsheng, Liu, Huan, Liu, Weiyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728072/
https://www.ncbi.nlm.nih.gov/pubmed/35002967
http://dx.doi.org/10.3389/fendo.2021.785604
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author Chen, Pianpian
Zha, Yunfei
Wang, Li
Li, Liang
Hu, Lei
Xing, Dong
Liu, Baiyu
Yang, Liu
Yang, Qi
Liu, Changsheng
Liu, Huan
Liu, Weiyin
author_facet Chen, Pianpian
Zha, Yunfei
Wang, Li
Li, Liang
Hu, Lei
Xing, Dong
Liu, Baiyu
Yang, Liu
Yang, Qi
Liu, Changsheng
Liu, Huan
Liu, Weiyin
author_sort Chen, Pianpian
collection PubMed
description PURPOSE: To investigate whether the microvascular permeability of lumbar marrow and bone trabecular changes in early-stage diabetic rabbits can be quantitatively evaluated using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), quantitative computed tomography, and texture-analyzed permeability parameter K(trans) map of DCE-MRI. MATERIALS AND METHODS: This prospective study included 24 rabbits that were randomly assigned to diabetic (n = 14) and control (n = 10) groups. All rabbits underwent sagittal MRI of the lumbar region at 0, 4, 8, 12, and 16 weeks after alloxan injection. Pearson correlation coefficient was performed to determine the correlation between permeability parameter and bone mineral density (BMD). Repeated-measures ANOVA was used to analyze the changes in lumbar BMD over time in each group and the texture parameters of diabetic rabbit lumbar marrow at different time points. Mann–Whitney U rank sum test was used to compare the differences of each index between the two groups and calculate the area under the curve (AUC). RESULTS: BMD was correlated with K(trans) , K(ep) , and V(e) but not with V(p) . At weeks 0–16, the BMD of the rabbits in the diabetic and normal groups was not statistically significant, but the change in BMD showed an overall downward trend. For texture analysis, entropy, energy, and Uniformized positive pixel (UPP) parameters extracted from the K(trans) map showed significant differences from week 0 to 16 between the two groups. The identification ability at 8–12 weeks was higher than that at 12–16 weeks, and the AUCs were 0.734, 0.766, and 0.734, respectively (P < 0.05 for all). CONCLUSIONS: The changes in BMD measured using quantitative computed tomography occurred later than those measured using bone trabecular morphometry. Texture analysis parameters based on DCE-MRI quantitative parameter Ktrans map are feasible to identify early changes in lumbar marrow structure in diabetic rabbits.
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spelling pubmed-87280722022-01-06 Evaluation of Bone Marrow Texture and Trabecular Changes With Quantitative DCE-MRI and QCT in Alloxan-Induced Diabetic Rabbit Models Chen, Pianpian Zha, Yunfei Wang, Li Li, Liang Hu, Lei Xing, Dong Liu, Baiyu Yang, Liu Yang, Qi Liu, Changsheng Liu, Huan Liu, Weiyin Front Endocrinol (Lausanne) Endocrinology PURPOSE: To investigate whether the microvascular permeability of lumbar marrow and bone trabecular changes in early-stage diabetic rabbits can be quantitatively evaluated using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), quantitative computed tomography, and texture-analyzed permeability parameter K(trans) map of DCE-MRI. MATERIALS AND METHODS: This prospective study included 24 rabbits that were randomly assigned to diabetic (n = 14) and control (n = 10) groups. All rabbits underwent sagittal MRI of the lumbar region at 0, 4, 8, 12, and 16 weeks after alloxan injection. Pearson correlation coefficient was performed to determine the correlation between permeability parameter and bone mineral density (BMD). Repeated-measures ANOVA was used to analyze the changes in lumbar BMD over time in each group and the texture parameters of diabetic rabbit lumbar marrow at different time points. Mann–Whitney U rank sum test was used to compare the differences of each index between the two groups and calculate the area under the curve (AUC). RESULTS: BMD was correlated with K(trans) , K(ep) , and V(e) but not with V(p) . At weeks 0–16, the BMD of the rabbits in the diabetic and normal groups was not statistically significant, but the change in BMD showed an overall downward trend. For texture analysis, entropy, energy, and Uniformized positive pixel (UPP) parameters extracted from the K(trans) map showed significant differences from week 0 to 16 between the two groups. The identification ability at 8–12 weeks was higher than that at 12–16 weeks, and the AUCs were 0.734, 0.766, and 0.734, respectively (P < 0.05 for all). CONCLUSIONS: The changes in BMD measured using quantitative computed tomography occurred later than those measured using bone trabecular morphometry. Texture analysis parameters based on DCE-MRI quantitative parameter Ktrans map are feasible to identify early changes in lumbar marrow structure in diabetic rabbits. Frontiers Media S.A. 2021-12-22 /pmc/articles/PMC8728072/ /pubmed/35002967 http://dx.doi.org/10.3389/fendo.2021.785604 Text en Copyright © 2021 Chen, Zha, Wang, Li, Hu, Xing, Liu, Yang, Yang, Liu, Liu and Liu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Chen, Pianpian
Zha, Yunfei
Wang, Li
Li, Liang
Hu, Lei
Xing, Dong
Liu, Baiyu
Yang, Liu
Yang, Qi
Liu, Changsheng
Liu, Huan
Liu, Weiyin
Evaluation of Bone Marrow Texture and Trabecular Changes With Quantitative DCE-MRI and QCT in Alloxan-Induced Diabetic Rabbit Models
title Evaluation of Bone Marrow Texture and Trabecular Changes With Quantitative DCE-MRI and QCT in Alloxan-Induced Diabetic Rabbit Models
title_full Evaluation of Bone Marrow Texture and Trabecular Changes With Quantitative DCE-MRI and QCT in Alloxan-Induced Diabetic Rabbit Models
title_fullStr Evaluation of Bone Marrow Texture and Trabecular Changes With Quantitative DCE-MRI and QCT in Alloxan-Induced Diabetic Rabbit Models
title_full_unstemmed Evaluation of Bone Marrow Texture and Trabecular Changes With Quantitative DCE-MRI and QCT in Alloxan-Induced Diabetic Rabbit Models
title_short Evaluation of Bone Marrow Texture and Trabecular Changes With Quantitative DCE-MRI and QCT in Alloxan-Induced Diabetic Rabbit Models
title_sort evaluation of bone marrow texture and trabecular changes with quantitative dce-mri and qct in alloxan-induced diabetic rabbit models
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728072/
https://www.ncbi.nlm.nih.gov/pubmed/35002967
http://dx.doi.org/10.3389/fendo.2021.785604
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