DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation

The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface,...

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Detalles Bibliográficos
Autores principales: Quaglia, Federica, Mészáros, Bálint, Salladini, Edoardo, Hatos, András, Pancsa, Rita, Chemes, Lucía B, Pajkos, Mátyás, Lazar, Tamas, Peña-Díaz, Samuel, Santos, Jaime, Ács, Veronika, Farahi, Nazanin, Fichó, Erzsébet, Aspromonte, Maria Cristina, Bassot, Claudio, Chasapi, Anastasia, Davey, Norman E, Davidović, Radoslav, Dobson, Laszlo, Elofsson, Arne, Erdős, Gábor, Gaudet, Pascale, Giglio, Michelle, Glavina, Juliana, Iserte, Javier, Iglesias, Valentín, Kálmán, Zsófia, Lambrughi, Matteo, Leonardi, Emanuela, Longhi, Sonia, Macedo-Ribeiro, Sandra, Maiani, Emiliano, Marchetti, Julia, Marino-Buslje, Cristina, Mészáros, Attila, Monzon, Alexander Miguel, Minervini, Giovanni, Nadendla, Suvarna, Nilsson, Juliet F, Novotný, Marian, Ouzounis, Christos A, Palopoli, Nicolás, Papaleo, Elena, Pereira, Pedro José Barbosa, Pozzati, Gabriele, Promponas, Vasilis J, Pujols, Jordi, Rocha, Alma Carolina Sanchez, Salas, Martin, Sawicki, Luciana Rodriguez, Schad, Eva, Shenoy, Aditi, Szaniszló, Tamás, Tsirigos, Konstantinos D, Veljkovic, Nevena, Parisi, Gustavo, Ventura, Salvador, Dosztányi, Zsuzsanna, Tompa, Peter, Tosatto, Silvio C E, Piovesan, Damiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Database Issue
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728214/
https://www.ncbi.nlm.nih.gov/pubmed/34850135
http://dx.doi.org/10.1093/nar/gkab1082
Descripción
Sumario:The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot.org) is the major repository of manually curated annotations of intrinsically disordered proteins and regions from the literature. We report here recent updates of DisProt version 9, including a restyled web interface, refactored Intrinsically Disordered Proteins Ontology (IDPO), improvements in the curation process and significant content growth of around 30%. Higher quality and consistency of annotations is provided by a newly implemented reviewing process and training of curators. The increased curation capacity is fostered by the integration of DisProt with APICURON, a dedicated resource for the proper attribution and recognition of biocuration efforts. Better interoperability is provided through the adoption of the Minimum Information About Disorder (MIADE) standard, an active collaboration with the Gene Ontology (GO) and Evidence and Conclusion Ontology (ECO) consortia and the support of the ELIXIR infrastructure.

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