Rhea, the reaction knowledgebase in 2022

Rhea (https://www.rhea-db.org) is an expert-curated knowledgebase of biochemical reactions based on the chemical ontology ChEBI (Chemical Entities of Biological Interest) (https://www.ebi.ac.uk/chebi). In this paper, we describe a number of key developments in Rhea since our last report in the datab...

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Autores principales: Bansal, Parit, Morgat, Anne, Axelsen, Kristian B, Muthukrishnan, Venkatesh, Coudert, Elisabeth, Aimo, Lucila, Hyka-Nouspikel, Nevila, Gasteiger, Elisabeth, Kerhornou, Arnaud, Neto, Teresa Batista, Pozzato, Monica, Blatter, Marie-Claude, Ignatchenko, Alex, Redaschi, Nicole, Bridge, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Database Issue
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728268/
https://www.ncbi.nlm.nih.gov/pubmed/34755880
http://dx.doi.org/10.1093/nar/gkab1016
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author Bansal, Parit
Morgat, Anne
Axelsen, Kristian B
Muthukrishnan, Venkatesh
Coudert, Elisabeth
Aimo, Lucila
Hyka-Nouspikel, Nevila
Gasteiger, Elisabeth
Kerhornou, Arnaud
Neto, Teresa Batista
Pozzato, Monica
Blatter, Marie-Claude
Ignatchenko, Alex
Redaschi, Nicole
Bridge, Alan
author_facet Bansal, Parit
Morgat, Anne
Axelsen, Kristian B
Muthukrishnan, Venkatesh
Coudert, Elisabeth
Aimo, Lucila
Hyka-Nouspikel, Nevila
Gasteiger, Elisabeth
Kerhornou, Arnaud
Neto, Teresa Batista
Pozzato, Monica
Blatter, Marie-Claude
Ignatchenko, Alex
Redaschi, Nicole
Bridge, Alan
author_sort Bansal, Parit
collection PubMed
description Rhea (https://www.rhea-db.org) is an expert-curated knowledgebase of biochemical reactions based on the chemical ontology ChEBI (Chemical Entities of Biological Interest) (https://www.ebi.ac.uk/chebi). In this paper, we describe a number of key developments in Rhea since our last report in the database issue of Nucleic Acids Research in 2019. These include improved reaction coverage in Rhea, the adoption of Rhea as the reference vocabulary for enzyme annotation in the UniProt knowledgebase UniProtKB (https://www.uniprot.org), the development of a new Rhea website, and the designation of Rhea as an ELIXIR Core Data Resource. We hope that these and other developments will enhance the utility of Rhea as a reference resource to study and engineer enzymes and the metabolic systems in which they function.
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spelling pubmed-87282682022-01-05 Rhea, the reaction knowledgebase in 2022 Bansal, Parit Morgat, Anne Axelsen, Kristian B Muthukrishnan, Venkatesh Coudert, Elisabeth Aimo, Lucila Hyka-Nouspikel, Nevila Gasteiger, Elisabeth Kerhornou, Arnaud Neto, Teresa Batista Pozzato, Monica Blatter, Marie-Claude Ignatchenko, Alex Redaschi, Nicole Bridge, Alan Nucleic Acids Res Database Issue Rhea (https://www.rhea-db.org) is an expert-curated knowledgebase of biochemical reactions based on the chemical ontology ChEBI (Chemical Entities of Biological Interest) (https://www.ebi.ac.uk/chebi). In this paper, we describe a number of key developments in Rhea since our last report in the database issue of Nucleic Acids Research in 2019. These include improved reaction coverage in Rhea, the adoption of Rhea as the reference vocabulary for enzyme annotation in the UniProt knowledgebase UniProtKB (https://www.uniprot.org), the development of a new Rhea website, and the designation of Rhea as an ELIXIR Core Data Resource. We hope that these and other developments will enhance the utility of Rhea as a reference resource to study and engineer enzymes and the metabolic systems in which they function. Oxford University Press 2021-11-10 /pmc/articles/PMC8728268/ /pubmed/34755880 http://dx.doi.org/10.1093/nar/gkab1016 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Database Issue
Bansal, Parit
Morgat, Anne
Axelsen, Kristian B
Muthukrishnan, Venkatesh
Coudert, Elisabeth
Aimo, Lucila
Hyka-Nouspikel, Nevila
Gasteiger, Elisabeth
Kerhornou, Arnaud
Neto, Teresa Batista
Pozzato, Monica
Blatter, Marie-Claude
Ignatchenko, Alex
Redaschi, Nicole
Bridge, Alan
Rhea, the reaction knowledgebase in 2022
title Rhea, the reaction knowledgebase in 2022
title_full Rhea, the reaction knowledgebase in 2022
title_fullStr Rhea, the reaction knowledgebase in 2022
title_full_unstemmed Rhea, the reaction knowledgebase in 2022
title_short Rhea, the reaction knowledgebase in 2022
title_sort rhea, the reaction knowledgebase in 2022
topic Database Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728268/
https://www.ncbi.nlm.nih.gov/pubmed/34755880
http://dx.doi.org/10.1093/nar/gkab1016
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