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DRAMP 3.0: an enhanced comprehensive data repository of antimicrobial peptides
Stapled antimicrobial peptides are an emerging class of artificial cyclic peptide molecules which have antimicrobial activity and potent structure stability. We previously published the Data Repository of Antimicrobial Peptides (DRAMP) as a manually annotated and open-access database of antimicrobia...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728287/ https://www.ncbi.nlm.nih.gov/pubmed/34390348 http://dx.doi.org/10.1093/nar/gkab651 |
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author | Shi, Guobang Kang, Xinyue Dong, Fanyi Liu, Yanchao Zhu, Ning Hu, Yuxuan Xu, Hanmei Lao, Xingzhen Zheng, Heng |
author_facet | Shi, Guobang Kang, Xinyue Dong, Fanyi Liu, Yanchao Zhu, Ning Hu, Yuxuan Xu, Hanmei Lao, Xingzhen Zheng, Heng |
author_sort | Shi, Guobang |
collection | PubMed |
description | Stapled antimicrobial peptides are an emerging class of artificial cyclic peptide molecules which have antimicrobial activity and potent structure stability. We previously published the Data Repository of Antimicrobial Peptides (DRAMP) as a manually annotated and open-access database of antimicrobial peptides (AMPs). In the update of version 3.0, special emphasis was placed on the new development of stapled AMPs, and a subclass of specific AMPs was added to store information on these special chemically modified AMPs. To help design low toxicity AMPs, we also added the cytotoxicity property of AMPs, as well as the expansion of newly discovered AMP data. At present, DRAMP has been expanded and contains 22259 entries (2360 newly added), consisting of 5891 general entries, 16110 patent entries, 77 clinical entries and 181 stapled AMPs. A total of 263 entries have predicted structures, and more than 300 general entries have links to experimentally determined structures in the Protein Data Bank. The update also covers new annotations, statistics, categories, functions and download links. DRAMP is available online at http://dramp.cpu-bioinfor.org/. |
format | Online Article Text |
id | pubmed-8728287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-87282872022-01-05 DRAMP 3.0: an enhanced comprehensive data repository of antimicrobial peptides Shi, Guobang Kang, Xinyue Dong, Fanyi Liu, Yanchao Zhu, Ning Hu, Yuxuan Xu, Hanmei Lao, Xingzhen Zheng, Heng Nucleic Acids Res Database Issue Stapled antimicrobial peptides are an emerging class of artificial cyclic peptide molecules which have antimicrobial activity and potent structure stability. We previously published the Data Repository of Antimicrobial Peptides (DRAMP) as a manually annotated and open-access database of antimicrobial peptides (AMPs). In the update of version 3.0, special emphasis was placed on the new development of stapled AMPs, and a subclass of specific AMPs was added to store information on these special chemically modified AMPs. To help design low toxicity AMPs, we also added the cytotoxicity property of AMPs, as well as the expansion of newly discovered AMP data. At present, DRAMP has been expanded and contains 22259 entries (2360 newly added), consisting of 5891 general entries, 16110 patent entries, 77 clinical entries and 181 stapled AMPs. A total of 263 entries have predicted structures, and more than 300 general entries have links to experimentally determined structures in the Protein Data Bank. The update also covers new annotations, statistics, categories, functions and download links. DRAMP is available online at http://dramp.cpu-bioinfor.org/. Oxford University Press 2021-08-14 /pmc/articles/PMC8728287/ /pubmed/34390348 http://dx.doi.org/10.1093/nar/gkab651 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Nucleic Acids Research. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Database Issue Shi, Guobang Kang, Xinyue Dong, Fanyi Liu, Yanchao Zhu, Ning Hu, Yuxuan Xu, Hanmei Lao, Xingzhen Zheng, Heng DRAMP 3.0: an enhanced comprehensive data repository of antimicrobial peptides |
title | DRAMP 3.0: an enhanced comprehensive data repository of antimicrobial peptides |
title_full | DRAMP 3.0: an enhanced comprehensive data repository of antimicrobial peptides |
title_fullStr | DRAMP 3.0: an enhanced comprehensive data repository of antimicrobial peptides |
title_full_unstemmed | DRAMP 3.0: an enhanced comprehensive data repository of antimicrobial peptides |
title_short | DRAMP 3.0: an enhanced comprehensive data repository of antimicrobial peptides |
title_sort | dramp 3.0: an enhanced comprehensive data repository of antimicrobial peptides |
topic | Database Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728287/ https://www.ncbi.nlm.nih.gov/pubmed/34390348 http://dx.doi.org/10.1093/nar/gkab651 |
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