Crotonylation sensitizes IAPi-induced disruption of latent HIV by enhancing p100 cleavage into p52

The eradication of HIV infection is difficult to achieve because of stable viral reservoirs. Here, we show that crotonylation enhances AZD5582-induced noncanonical NF-κB (ncNF-κB) signaling, further augmenting HIV latency reversal in Jurkat and U1 cell line models of latency, HIV latently infected p...

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Detalles Bibliográficos
Autores principales: Li, Dajiang, Dewey, Morgan G., Wang, Li, Falcinelli, Shane D., Wong, Lilly M., Tang, Yuyang, Browne, Edward P., Chen, Xian, Archin, Nancie M., Margolis, David M., Jiang, Guochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728431/
https://www.ncbi.nlm.nih.gov/pubmed/35024584
http://dx.doi.org/10.1016/j.isci.2021.103649

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