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Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine
S-adenosylmethionine (SAM) is a versatile metabolite that participates in a wide range of reactions such as methylation and transsulfuration. These capabilities allow SAM to influence cellular processes such as gene expression and redox balancing. The importance of SAM is highlighted by its widespre...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shared Science Publishers OG
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728568/ https://www.ncbi.nlm.nih.gov/pubmed/35083422 http://dx.doi.org/10.15698/cst2022.01.261 |
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author | Sun, Yudong Locasale, Jason W. |
author_facet | Sun, Yudong Locasale, Jason W. |
author_sort | Sun, Yudong |
collection | PubMed |
description | S-adenosylmethionine (SAM) is a versatile metabolite that participates in a wide range of reactions such as methylation and transsulfuration. These capabilities allow SAM to influence cellular processes such as gene expression and redox balancing. The importance of SAM is highlighted by its widespread usage as an over-the-counter nutrient supplement and as an experimental reagent in molecular biology. The bioavailability and cellular transport properties of SAM, however, are often overlooked under these contexts, putting limits on SAM's therapeutic potential and complicating the interpretation of experimental results. In this article, we examined the chemical stability and cellular permeability of SAM, proposed a schematic for indirect SAM transport across the mammalian plasma membrane, and lastly discussed the implications arising from such transport schematic. |
format | Online Article Text |
id | pubmed-8728568 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Shared Science Publishers OG |
record_format | MEDLINE/PubMed |
spelling | pubmed-87285682022-01-25 Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine Sun, Yudong Locasale, Jason W. Cell Stress Viewpoint S-adenosylmethionine (SAM) is a versatile metabolite that participates in a wide range of reactions such as methylation and transsulfuration. These capabilities allow SAM to influence cellular processes such as gene expression and redox balancing. The importance of SAM is highlighted by its widespread usage as an over-the-counter nutrient supplement and as an experimental reagent in molecular biology. The bioavailability and cellular transport properties of SAM, however, are often overlooked under these contexts, putting limits on SAM's therapeutic potential and complicating the interpretation of experimental results. In this article, we examined the chemical stability and cellular permeability of SAM, proposed a schematic for indirect SAM transport across the mammalian plasma membrane, and lastly discussed the implications arising from such transport schematic. Shared Science Publishers OG 2021-12-06 /pmc/articles/PMC8728568/ /pubmed/35083422 http://dx.doi.org/10.15698/cst2022.01.261 Text en Copyright: © 2021 Sun and Locasale https://creativecommons.org/licenses/by/4.0/This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged. |
spellingShingle | Viewpoint Sun, Yudong Locasale, Jason W. Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine |
title | Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine |
title_full | Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine |
title_fullStr | Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine |
title_full_unstemmed | Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine |
title_short | Rethinking the bioavailability and cellular transport properties of S-adenosylmethionine |
title_sort | rethinking the bioavailability and cellular transport properties of s-adenosylmethionine |
topic | Viewpoint |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728568/ https://www.ncbi.nlm.nih.gov/pubmed/35083422 http://dx.doi.org/10.15698/cst2022.01.261 |
work_keys_str_mv | AT sunyudong rethinkingthebioavailabilityandcellulartransportpropertiesofsadenosylmethionine AT locasalejasonw rethinkingthebioavailabilityandcellulartransportpropertiesofsadenosylmethionine |