Blocking phosphatidylglycerol degradation in yeast defective in cardiolipin remodeling results in a new model of the Barth syndrome cellular phenotype

Barth syndrome (BTHS) is an inherited mitochondrial disorder characterized by a decrease in total cardiolipin and the accumulation of its precursor monolysocardiolipin due to the loss of the transacylase enzyme tafazzin. However, the molecular basis of BTHS pathology is still not well understood. He...

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Detalles Bibliográficos
Autores principales: Káňovičová, Paulína, Čermáková, Petra, Kubalová, Dominika, Bábelová, Lenka, Veselá, Petra, Valachovič, Martin, Zahumenský, Jakub, Horváth, Anton, Malínský, Jan, Balážová, Mária
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728584/
https://www.ncbi.nlm.nih.gov/pubmed/34864056
http://dx.doi.org/10.1016/j.jbc.2021.101462

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