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Metabolic resistance to the inhibition of mitochondrial transcription revealed by CRISPR‐Cas9 screen

Cancer cells depend on mitochondria to sustain their increased metabolic need and mitochondria therefore constitute possible targets for cancer treatment. We recently developed small‐molecule inhibitors of mitochondrial transcription (IMTs) that selectively impair mitochondrial gene expression. IMTs...

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Detalles Bibliográficos
Autores principales:	Mennuni, Mara, Filograna, Roberta, Felser, Andrea, Bonekamp, Nina A, Giavalisco, Patrick, Lytovchenko, Oleksandr, Larsson, Nils‐Göran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728608/ https://www.ncbi.nlm.nih.gov/pubmed/34779571 http://dx.doi.org/10.15252/embr.202153054

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