Impact of Intestinal Concentration and Colloidal Structure on the Permeation-Enhancing Efficiency of Sodium Caprate in the Rat

[Image: see text] In this work, we set out to better understand how the permeation enhancer sodium caprate (C10) influences the intestinal absorption of macromolecules. FITC-dextran 4000 (FD4) was selected as a model compound and formulated with 50–300 mM C10. Absorption was studied after bolus inst...

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Detalles Bibliográficos
Autores principales: Berg, Staffan, Kärrberg, Lillevi, Suljovic, Denny, Seeliger, Frank, Söderberg, Magnus, Perez-Alcazar, Marta, Van Zuydam, Natalie, Abrahamsson, Bertil, Hugerth, Andreas M, Davies, Nigel, Bergström, Christel A. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728734/
https://www.ncbi.nlm.nih.gov/pubmed/34928160
http://dx.doi.org/10.1021/acs.molpharmaceut.1c00724

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