Diphtheria toxin induced but not CSF1R inhibitor mediated microglia ablation model leads to the loss of CSF/ventricular spaces in vivo that is independent of cytokine upregulation

BACKGROUND: Two recently developed novel rodent models have been reported to ablate microglia, either by genetically targeting microglia (via Cx3cr1-creER: iDTR + Dtx) or through pharmacologically targeting the CSF1R receptor with its inhibitor (PLX5622). Both models have been widely used in recent...

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Detalles Bibliográficos
Autores principales: Bedolla, Alicia, Taranov, Aleksandr, Luo, Fucheng, Wang, Jiapeng, Turcato, Flavia, Fugate, Elizabeth M., Greig, Nigel H., Lindquist, Diana M., Crone, Steven A., Goto, June, Luo, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8728932/
https://www.ncbi.nlm.nih.gov/pubmed/34983562
http://dx.doi.org/10.1186/s12974-021-02367-w

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