Cargando…

Barrett's esophagus: The pathomorphological and molecular genetic keystones of neoplastic progression

Barrett's esophagus is a widespread chronically progressing disease of heterogeneous nature. A life threatening complication of this condition is neoplastic transformation, which is often overlooked due to lack of standardized approaches in diagnosis, preventative measures and treatment. In thi...

Descripción completa

Detalles Bibliográficos
Autores principales: Maslyonkina, Ksenia S., Konyukova, Alexandra K., Alexeeva, Darya Y., Sinelnikov, Mikhail Y., Mikhaleva, Liudmila M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8729054/
https://www.ncbi.nlm.nih.gov/pubmed/34870375
http://dx.doi.org/10.1002/cam4.4447
_version_ 1784626859150934016
author Maslyonkina, Ksenia S.
Konyukova, Alexandra K.
Alexeeva, Darya Y.
Sinelnikov, Mikhail Y.
Mikhaleva, Liudmila M.
author_facet Maslyonkina, Ksenia S.
Konyukova, Alexandra K.
Alexeeva, Darya Y.
Sinelnikov, Mikhail Y.
Mikhaleva, Liudmila M.
author_sort Maslyonkina, Ksenia S.
collection PubMed
description Barrett's esophagus is a widespread chronically progressing disease of heterogeneous nature. A life threatening complication of this condition is neoplastic transformation, which is often overlooked due to lack of standardized approaches in diagnosis, preventative measures and treatment. In this essay, we aim to stratify existing data to show specific associations between neoplastic transformation and the underlying processes which predate cancerous transition. We discuss pathomorphological, genetic, epigenetic, molecular and immunohistochemical methods related to neoplasia detection on the basis of Barrett's esophagus. Our review sheds light on pathways of such neoplastic progression in the distal esophagus, providing valuable insight into progression assessment, preventative targets and treatment modalities. Our results suggest that molecular, genetic and epigenetic alterations in the esophagus arise earlier than cancerous transformation, meaning the discussed targets can help form preventative strategies in at‐risk patient groups.
format Online
Article
Text
id pubmed-8729054
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-87290542022-01-11 Barrett's esophagus: The pathomorphological and molecular genetic keystones of neoplastic progression Maslyonkina, Ksenia S. Konyukova, Alexandra K. Alexeeva, Darya Y. Sinelnikov, Mikhail Y. Mikhaleva, Liudmila M. Cancer Med Cancer Biology Barrett's esophagus is a widespread chronically progressing disease of heterogeneous nature. A life threatening complication of this condition is neoplastic transformation, which is often overlooked due to lack of standardized approaches in diagnosis, preventative measures and treatment. In this essay, we aim to stratify existing data to show specific associations between neoplastic transformation and the underlying processes which predate cancerous transition. We discuss pathomorphological, genetic, epigenetic, molecular and immunohistochemical methods related to neoplasia detection on the basis of Barrett's esophagus. Our review sheds light on pathways of such neoplastic progression in the distal esophagus, providing valuable insight into progression assessment, preventative targets and treatment modalities. Our results suggest that molecular, genetic and epigenetic alterations in the esophagus arise earlier than cancerous transformation, meaning the discussed targets can help form preventative strategies in at‐risk patient groups. John Wiley and Sons Inc. 2021-12-06 /pmc/articles/PMC8729054/ /pubmed/34870375 http://dx.doi.org/10.1002/cam4.4447 Text en © 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cancer Biology
Maslyonkina, Ksenia S.
Konyukova, Alexandra K.
Alexeeva, Darya Y.
Sinelnikov, Mikhail Y.
Mikhaleva, Liudmila M.
Barrett's esophagus: The pathomorphological and molecular genetic keystones of neoplastic progression
title Barrett's esophagus: The pathomorphological and molecular genetic keystones of neoplastic progression
title_full Barrett's esophagus: The pathomorphological and molecular genetic keystones of neoplastic progression
title_fullStr Barrett's esophagus: The pathomorphological and molecular genetic keystones of neoplastic progression
title_full_unstemmed Barrett's esophagus: The pathomorphological and molecular genetic keystones of neoplastic progression
title_short Barrett's esophagus: The pathomorphological and molecular genetic keystones of neoplastic progression
title_sort barrett's esophagus: the pathomorphological and molecular genetic keystones of neoplastic progression
topic Cancer Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8729054/
https://www.ncbi.nlm.nih.gov/pubmed/34870375
http://dx.doi.org/10.1002/cam4.4447
work_keys_str_mv AT maslyonkinaksenias barrettsesophagusthepathomorphologicalandmoleculargenetickeystonesofneoplasticprogression
AT konyukovaalexandrak barrettsesophagusthepathomorphologicalandmoleculargenetickeystonesofneoplasticprogression
AT alexeevadaryay barrettsesophagusthepathomorphologicalandmoleculargenetickeystonesofneoplasticprogression
AT sinelnikovmikhaily barrettsesophagusthepathomorphologicalandmoleculargenetickeystonesofneoplasticprogression
AT mikhalevaliudmilam barrettsesophagusthepathomorphologicalandmoleculargenetickeystonesofneoplasticprogression