Chemoproteomic-enabled characterization of small GTPase Rab1a as a target of an N-arylbenzimidazole ligand's rescue of Parkinson's-associated cell toxicity

The development of phenotypic models of Parkinson's disease (PD) has enabled screening and identification of phenotypically active small molecules that restore complex biological pathways affected by PD toxicity. While these phenotypic screening platforms are powerful, they do not inherently en...

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Detalles Bibliográficos
Autores principales: Hatstat, A. Katherine, Quan, Baiyi, Bailey, Morgan A., Fitzgerald, Michael C., Reinhart, Michaela C., McCafferty, Dewey G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8729260/
https://www.ncbi.nlm.nih.gov/pubmed/35128413
http://dx.doi.org/10.1039/d1cb00103e

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