Chaperones mainly suppress primary nucleation during formation of functional amyloid required for bacterial biofilm formation

Unlike misfolding in neurodegenerative diseases, aggregation of functional amyloids involved in bacterial biofilm, e.g. CsgA (E. coli) and FapC (Pseudomonas), is carefully regulated. However, it is unclear whether functional aggregation is inhibited by chaperones targeting pathological misfolding an...

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Detalles Bibliográficos
Autores principales: Nagaraj, Madhu, Najarzadeh, Zahra, Pansieri, Jonathan, Biverstål, Henrik, Musteikyte, Greta, Smirnovas, Vytautas, Matthews, Steve, Emanuelsson, Cecilia, Johansson, Janne, Buxbaum, Joel N., Morozova-Roche, Ludmilla, Otzen, Daniel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8729806/
https://www.ncbi.nlm.nih.gov/pubmed/35126986
http://dx.doi.org/10.1039/d1sc05790a

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