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A Telemedicine-Guided Self-Collection Approach for PCR-Based SARS-CoV-2 Testing: Comparative Study
BACKGROUND: Large-scale, polymerase chain reaction (PCR)-based SARS-CoV-2 testing is expensive, resource intensive, and time consuming. A self-collection approach is a probable alternative; however, its feasibility, cost, and ability to prevent infections need to be evaluated. OBJECTIVE: This study...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JMIR Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8729873/ https://www.ncbi.nlm.nih.gov/pubmed/34803022 http://dx.doi.org/10.2196/32564 |
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author | Würstle, Silvia Erber, Johanna Hanselmann, Michael Hoffmann, Dieter Werfel, Stanislas Hering, Svenja Weidlich, Simon Schneider, Jochen Franke, Ralf Maier, Michael Henkel, Andreas G Schmid, Roland M Protzer, Ulrike Laxy, Michael Spinner, Christoph D |
author_facet | Würstle, Silvia Erber, Johanna Hanselmann, Michael Hoffmann, Dieter Werfel, Stanislas Hering, Svenja Weidlich, Simon Schneider, Jochen Franke, Ralf Maier, Michael Henkel, Andreas G Schmid, Roland M Protzer, Ulrike Laxy, Michael Spinner, Christoph D |
author_sort | Würstle, Silvia |
collection | PubMed |
description | BACKGROUND: Large-scale, polymerase chain reaction (PCR)-based SARS-CoV-2 testing is expensive, resource intensive, and time consuming. A self-collection approach is a probable alternative; however, its feasibility, cost, and ability to prevent infections need to be evaluated. OBJECTIVE: This study aims to compare an innovative self-collection approach with a regular SARS-CoV-2 testing strategy in a large European industrial manufacturing site. METHODS: The feasibility of a telemedicine-guided PCR-based self-collection approach was assessed for 150 employees (intervention group) and compared with a regular SARS-CoV-2 testing approach used for 143 employees (control group). Acceptance, ergonomics, and efficacy were evaluated using a software application. A simulation model was implemented to evaluate the effectiveness. An interactive R shiny app was created to enable customized simulations. RESULTS: The test results were successfully communicated to and interpreted without uncertainty by 76% (114/150) and 76.9% (110/143) of the participants in the intervention and control groups, respectively (P=.96). The ratings for acceptability, ergonomics, and efficacy among intervention group participants were noninferior when compared to those among control group participants (acceptability: 71.6% vs 37.6%; ergonomics: 88.1% vs 74.5%; efficacy: 86.4% vs 77.5%). The self-collection approach was found to be less time consuming (23 min vs 38 min; P<.001). The simulation model indicated that both testing approaches reduce the risk of infection, and the self-collection approach tends to be slightly less effective owing to its lower sensitivity. CONCLUSIONS: The self-collection approach for SARS-CoV-2 diagnosis was found to be technically feasible and well rated in terms of acceptance, ergonomics, and efficacy. The simulation model facilitates the evaluation of test effectiveness; nonetheless, considering context specificity, appropriate adaptation by companies is required. |
format | Online Article Text |
id | pubmed-8729873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | JMIR Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-87298732022-01-21 A Telemedicine-Guided Self-Collection Approach for PCR-Based SARS-CoV-2 Testing: Comparative Study Würstle, Silvia Erber, Johanna Hanselmann, Michael Hoffmann, Dieter Werfel, Stanislas Hering, Svenja Weidlich, Simon Schneider, Jochen Franke, Ralf Maier, Michael Henkel, Andreas G Schmid, Roland M Protzer, Ulrike Laxy, Michael Spinner, Christoph D JMIR Form Res Original Paper BACKGROUND: Large-scale, polymerase chain reaction (PCR)-based SARS-CoV-2 testing is expensive, resource intensive, and time consuming. A self-collection approach is a probable alternative; however, its feasibility, cost, and ability to prevent infections need to be evaluated. OBJECTIVE: This study aims to compare an innovative self-collection approach with a regular SARS-CoV-2 testing strategy in a large European industrial manufacturing site. METHODS: The feasibility of a telemedicine-guided PCR-based self-collection approach was assessed for 150 employees (intervention group) and compared with a regular SARS-CoV-2 testing approach used for 143 employees (control group). Acceptance, ergonomics, and efficacy were evaluated using a software application. A simulation model was implemented to evaluate the effectiveness. An interactive R shiny app was created to enable customized simulations. RESULTS: The test results were successfully communicated to and interpreted without uncertainty by 76% (114/150) and 76.9% (110/143) of the participants in the intervention and control groups, respectively (P=.96). The ratings for acceptability, ergonomics, and efficacy among intervention group participants were noninferior when compared to those among control group participants (acceptability: 71.6% vs 37.6%; ergonomics: 88.1% vs 74.5%; efficacy: 86.4% vs 77.5%). The self-collection approach was found to be less time consuming (23 min vs 38 min; P<.001). The simulation model indicated that both testing approaches reduce the risk of infection, and the self-collection approach tends to be slightly less effective owing to its lower sensitivity. CONCLUSIONS: The self-collection approach for SARS-CoV-2 diagnosis was found to be technically feasible and well rated in terms of acceptance, ergonomics, and efficacy. The simulation model facilitates the evaluation of test effectiveness; nonetheless, considering context specificity, appropriate adaptation by companies is required. JMIR Publications 2022-01-04 /pmc/articles/PMC8729873/ /pubmed/34803022 http://dx.doi.org/10.2196/32564 Text en ©Silvia Würstle, Johanna Erber, Michael Hanselmann, Dieter Hoffmann, Stanislas Werfel, Svenja Hering, Simon Weidlich, Jochen Schneider, Ralf Franke, Michael Maier, Andreas G Henkel, Roland M Schmid, Ulrike Protzer, Michael Laxy, Christoph D Spinner. Originally published in JMIR Formative Research (https://formative.jmir.org), 04.01.2022. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in JMIR Formative Research, is properly cited. The complete bibliographic information, a link to the original publication on https://formative.jmir.org, as well as this copyright and license information must be included. |
spellingShingle | Original Paper Würstle, Silvia Erber, Johanna Hanselmann, Michael Hoffmann, Dieter Werfel, Stanislas Hering, Svenja Weidlich, Simon Schneider, Jochen Franke, Ralf Maier, Michael Henkel, Andreas G Schmid, Roland M Protzer, Ulrike Laxy, Michael Spinner, Christoph D A Telemedicine-Guided Self-Collection Approach for PCR-Based SARS-CoV-2 Testing: Comparative Study |
title | A Telemedicine-Guided Self-Collection Approach for PCR-Based SARS-CoV-2 Testing: Comparative Study |
title_full | A Telemedicine-Guided Self-Collection Approach for PCR-Based SARS-CoV-2 Testing: Comparative Study |
title_fullStr | A Telemedicine-Guided Self-Collection Approach for PCR-Based SARS-CoV-2 Testing: Comparative Study |
title_full_unstemmed | A Telemedicine-Guided Self-Collection Approach for PCR-Based SARS-CoV-2 Testing: Comparative Study |
title_short | A Telemedicine-Guided Self-Collection Approach for PCR-Based SARS-CoV-2 Testing: Comparative Study |
title_sort | telemedicine-guided self-collection approach for pcr-based sars-cov-2 testing: comparative study |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8729873/ https://www.ncbi.nlm.nih.gov/pubmed/34803022 http://dx.doi.org/10.2196/32564 |
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