Cargando…
Identification of Peptoniphilus harei From Blood Cultures in an Infected Aortic Aneurysm Patient: Case Report and Review Published Literature
Gram-positive anaerobic cocci (GPAC) are a commensal part of human flora but are also opportunistic pathogens. This is possibly the first study to report a case of Peptoniphilus harei bacteremia in an abdominal aortic aneurysm (AAA) patient. Matrix-assisted laser desorption ionization time-of-flight...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730293/ https://www.ncbi.nlm.nih.gov/pubmed/35004343 http://dx.doi.org/10.3389/fcimb.2021.755225 |
_version_ | 1784627109746966528 |
---|---|
author | Wan, Xue Wang, Shuang Wang, Min Liu, Jinhua Zhang, Yu |
author_facet | Wan, Xue Wang, Shuang Wang, Min Liu, Jinhua Zhang, Yu |
author_sort | Wan, Xue |
collection | PubMed |
description | Gram-positive anaerobic cocci (GPAC) are a commensal part of human flora but are also opportunistic pathogens. This is possibly the first study to report a case of Peptoniphilus harei bacteremia in an abdominal aortic aneurysm (AAA) patient. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) failed to identify the isolate and molecular analysis confirmed it as P. harei. A comprehensive literature review revealed that P. harei is an emergent pathogen. This study serves as a reminder for practicing clinicians to include anaerobic blood cultures as part of their blood culture procedures; this is particularly important situations with a high level of suspicion of infection factors in some noninfectious diseases, as mentioned in this publication. Clinical microbiologists should be aware that the pathogenic potential of GPAC can be greatly underestimated leading to incorrect diagnosis on using only one method for pathogen identification. Upgradation and correction of the MALDI-TOF MS databases is recommended to provide reliable and rapid identification of GPAC at species level in medical diagnostic microbiology laboratories. |
format | Online Article Text |
id | pubmed-8730293 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87302932022-01-06 Identification of Peptoniphilus harei From Blood Cultures in an Infected Aortic Aneurysm Patient: Case Report and Review Published Literature Wan, Xue Wang, Shuang Wang, Min Liu, Jinhua Zhang, Yu Front Cell Infect Microbiol Cellular and Infection Microbiology Gram-positive anaerobic cocci (GPAC) are a commensal part of human flora but are also opportunistic pathogens. This is possibly the first study to report a case of Peptoniphilus harei bacteremia in an abdominal aortic aneurysm (AAA) patient. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) failed to identify the isolate and molecular analysis confirmed it as P. harei. A comprehensive literature review revealed that P. harei is an emergent pathogen. This study serves as a reminder for practicing clinicians to include anaerobic blood cultures as part of their blood culture procedures; this is particularly important situations with a high level of suspicion of infection factors in some noninfectious diseases, as mentioned in this publication. Clinical microbiologists should be aware that the pathogenic potential of GPAC can be greatly underestimated leading to incorrect diagnosis on using only one method for pathogen identification. Upgradation and correction of the MALDI-TOF MS databases is recommended to provide reliable and rapid identification of GPAC at species level in medical diagnostic microbiology laboratories. Frontiers Media S.A. 2021-12-22 /pmc/articles/PMC8730293/ /pubmed/35004343 http://dx.doi.org/10.3389/fcimb.2021.755225 Text en Copyright © 2021 Wan, Wang, Wang, Liu and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Wan, Xue Wang, Shuang Wang, Min Liu, Jinhua Zhang, Yu Identification of Peptoniphilus harei From Blood Cultures in an Infected Aortic Aneurysm Patient: Case Report and Review Published Literature |
title | Identification of Peptoniphilus harei From Blood Cultures in an Infected Aortic Aneurysm Patient: Case Report and Review Published Literature |
title_full | Identification of Peptoniphilus harei From Blood Cultures in an Infected Aortic Aneurysm Patient: Case Report and Review Published Literature |
title_fullStr | Identification of Peptoniphilus harei From Blood Cultures in an Infected Aortic Aneurysm Patient: Case Report and Review Published Literature |
title_full_unstemmed | Identification of Peptoniphilus harei From Blood Cultures in an Infected Aortic Aneurysm Patient: Case Report and Review Published Literature |
title_short | Identification of Peptoniphilus harei From Blood Cultures in an Infected Aortic Aneurysm Patient: Case Report and Review Published Literature |
title_sort | identification of peptoniphilus harei from blood cultures in an infected aortic aneurysm patient: case report and review published literature |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730293/ https://www.ncbi.nlm.nih.gov/pubmed/35004343 http://dx.doi.org/10.3389/fcimb.2021.755225 |
work_keys_str_mv | AT wanxue identificationofpeptoniphilushareifrombloodculturesinaninfectedaorticaneurysmpatientcasereportandreviewpublishedliterature AT wangshuang identificationofpeptoniphilushareifrombloodculturesinaninfectedaorticaneurysmpatientcasereportandreviewpublishedliterature AT wangmin identificationofpeptoniphilushareifrombloodculturesinaninfectedaorticaneurysmpatientcasereportandreviewpublishedliterature AT liujinhua identificationofpeptoniphilushareifrombloodculturesinaninfectedaorticaneurysmpatientcasereportandreviewpublishedliterature AT zhangyu identificationofpeptoniphilushareifrombloodculturesinaninfectedaorticaneurysmpatientcasereportandreviewpublishedliterature |