Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification

Uracil arises in cellular DNA by cytosine (C) deamination and erroneous replicative incorporation of deoxyuridine monophosphate opposite adenine. The former generates C → thymine transition mutations if uracil is not removed by uracil-DNA glycosylase (UDG) and replaced by C by the base excision repa...

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Detalles Bibliográficos
Autores principales: Alexeeva, Marina, Moen, Marivi Nabong, Xu, Xiang Ming, Rasmussen, Anette, Leiros, Ingar, Kirpekar, Finn, Klungland, Arne, Alsøe, Lene, Nilsen, Hilde, Bjelland, Svein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730318/
https://www.ncbi.nlm.nih.gov/pubmed/35003074
http://dx.doi.org/10.3389/fimmu.2021.762032

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