Cerebral amyloid angiopathy: early presentation in a patient with prior neurosurgical interventions. Case report

BACKGROUND: Cerebral amyloid angiopathy (CAA) has classically been described as a disease of the elderly. Genetic predisposition has been linked to the APOE e3/e3 allele. Evidence suggests that brain insult in the form of injury, prior surgical intervention, or radiation can exacerbate the clearance...

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Autores principales: Clark, Alec, Barpujari, Arnav, Lucke-Wold, Brandon, Porche, Ken, Laurent, Dimitri, Koch, Matthew, Decker, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730372/
https://www.ncbi.nlm.nih.gov/pubmed/34992489
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author Clark, Alec
Barpujari, Arnav
Lucke-Wold, Brandon
Porche, Ken
Laurent, Dimitri
Koch, Matthew
Decker, Matthew
author_facet Clark, Alec
Barpujari, Arnav
Lucke-Wold, Brandon
Porche, Ken
Laurent, Dimitri
Koch, Matthew
Decker, Matthew
author_sort Clark, Alec
collection PubMed
description BACKGROUND: Cerebral amyloid angiopathy (CAA) has classically been described as a disease of the elderly. Genetic predisposition has been linked to the APOE e3/e3 allele. Evidence suggests that brain insult in the form of injury, prior surgical intervention, or radiation can exacerbate the clearance of toxic proteins in patients susceptible to CAA. CASE: We describe a unique case of CAA in a 30-year-old male who had prior surgical interventions for spina bifida, Chiari malformation, and hydrocephalus as a child. CONCLUSIONS: The case is used to teach important components regarding diagnosis, clinical suspicion, and highlight the need for further investigation regarding the emerging role of the glymphatic system and its role in clinical pathology.
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spelling pubmed-87303722022-01-05 Cerebral amyloid angiopathy: early presentation in a patient with prior neurosurgical interventions. Case report Clark, Alec Barpujari, Arnav Lucke-Wold, Brandon Porche, Ken Laurent, Dimitri Koch, Matthew Decker, Matthew Rom Neurosurg Article BACKGROUND: Cerebral amyloid angiopathy (CAA) has classically been described as a disease of the elderly. Genetic predisposition has been linked to the APOE e3/e3 allele. Evidence suggests that brain insult in the form of injury, prior surgical intervention, or radiation can exacerbate the clearance of toxic proteins in patients susceptible to CAA. CASE: We describe a unique case of CAA in a 30-year-old male who had prior surgical interventions for spina bifida, Chiari malformation, and hydrocephalus as a child. CONCLUSIONS: The case is used to teach important components regarding diagnosis, clinical suspicion, and highlight the need for further investigation regarding the emerging role of the glymphatic system and its role in clinical pathology. 2021-12-15 /pmc/articles/PMC8730372/ /pubmed/34992489 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License (https://creativecommons.org/licenses/by-nc-nd/4.0/) which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited.
spellingShingle Article
Clark, Alec
Barpujari, Arnav
Lucke-Wold, Brandon
Porche, Ken
Laurent, Dimitri
Koch, Matthew
Decker, Matthew
Cerebral amyloid angiopathy: early presentation in a patient with prior neurosurgical interventions. Case report
title Cerebral amyloid angiopathy: early presentation in a patient with prior neurosurgical interventions. Case report
title_full Cerebral amyloid angiopathy: early presentation in a patient with prior neurosurgical interventions. Case report
title_fullStr Cerebral amyloid angiopathy: early presentation in a patient with prior neurosurgical interventions. Case report
title_full_unstemmed Cerebral amyloid angiopathy: early presentation in a patient with prior neurosurgical interventions. Case report
title_short Cerebral amyloid angiopathy: early presentation in a patient with prior neurosurgical interventions. Case report
title_sort cerebral amyloid angiopathy: early presentation in a patient with prior neurosurgical interventions. case report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730372/
https://www.ncbi.nlm.nih.gov/pubmed/34992489
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