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Detection of MDM2 amplification by shallow whole genome sequencing of cell-free DNA of patients with dedifferentiated liposarcoma

High-level amplification of MDM2 and other genes in the 12q13–15 locus is a hallmark genetic feature of well-differentiated and dedifferentiated liposarcomas (WDLPS and DDLPS, respectively). Detection of this genomic aberration in plasma cell-free DNA may be a clinically useful assay for non-invasiv...

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Detalles Bibliográficos
Autores principales:	Przybyl, Joanna, Spans, Lien, Ganjoo, Kristen, Bui, Nam, Mohler, David, Norton, Jeffrey, Poultsides, George, Debiec-Rychter, Maria, van de Rijn, Matt
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730389/ https://www.ncbi.nlm.nih.gov/pubmed/34986184 http://dx.doi.org/10.1371/journal.pone.0262272

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