Evolutionary pathways to SARS-CoV-2 resistance are opened and closed by epistasis acting on ACE2

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infects a broader range of mammalian species than previously predicted, binding a diversity of angiotensin converting enzyme 2 (ACE2) orthologs despite extensive sequence divergence. Within this sequence degeneracy, we identify a rare sequ...

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Detalles Bibliográficos
Autores principales: Castiglione, Gianni M., Zhou, Lingli, Xu, Zhenhua, Neiman, Zachary, Hung, Chien-Fu, Duh, Elia J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730403/
https://www.ncbi.nlm.nih.gov/pubmed/34932561
http://dx.doi.org/10.1371/journal.pbio.3001510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730403/
https://www.ncbi.nlm.nih.gov/pubmed/34932561
http://dx.doi.org/10.1371/journal.pbio.3001510

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