Cargando…
Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine
Pneumococcal conjugate vaccines reduce the burden of invasive pneumococcal disease, but the sustained effect of these vaccines can be diminished by an increase in disease caused by non-vaccine serotypes. To describe pneumococcal serotype epidemiology in Botswana following introduction of 13-valent p...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730465/ https://www.ncbi.nlm.nih.gov/pubmed/34986196 http://dx.doi.org/10.1371/journal.pone.0262225 |
_version_ | 1784627145274818560 |
---|---|
author | Patel, Sweta M. Shaik-Dasthagirisaheb, Yazdani B. Congdon, Morgan Young, Rebecca R. Patel, Mohamed Z. Mazhani, Tiny Boiditswe, Sefelani Leburu, Tirayaone Lechiile, Kwana Arscott-Mills, Tonya Steenhoff, Andrew P. Feemster, Kristen A. Shah, Samir S. Cunningham, Coleen K. Pelton, Stephen I. Kelly, Matthew S. |
author_facet | Patel, Sweta M. Shaik-Dasthagirisaheb, Yazdani B. Congdon, Morgan Young, Rebecca R. Patel, Mohamed Z. Mazhani, Tiny Boiditswe, Sefelani Leburu, Tirayaone Lechiile, Kwana Arscott-Mills, Tonya Steenhoff, Andrew P. Feemster, Kristen A. Shah, Samir S. Cunningham, Coleen K. Pelton, Stephen I. Kelly, Matthew S. |
author_sort | Patel, Sweta M. |
collection | PubMed |
description | Pneumococcal conjugate vaccines reduce the burden of invasive pneumococcal disease, but the sustained effect of these vaccines can be diminished by an increase in disease caused by non-vaccine serotypes. To describe pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine (PCV-13) in July 2012, we performed molecular serotyping of 268 pneumococcal strains isolated from 221 children between 2012 and 2017. The median (interquartile range) age of the children included in this analysis was 6 (3,12) months. Fifty-nine percent of the children had received at least one dose of PCV-13 and 35% were fully vaccinated with PCV-13. While colonization by vaccine serotypes steadily declined following PCV-13 introduction, 25% of strains isolated more than 3 years after vaccine introduction were PCV-13 serotypes. We also observed an increase in colonization by non-vaccine serotypes 21 and 23B, which have been associated with invasive pneumococcal disease and antibiotic resistance in other settings. |
format | Online Article Text |
id | pubmed-8730465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-87304652022-01-06 Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine Patel, Sweta M. Shaik-Dasthagirisaheb, Yazdani B. Congdon, Morgan Young, Rebecca R. Patel, Mohamed Z. Mazhani, Tiny Boiditswe, Sefelani Leburu, Tirayaone Lechiile, Kwana Arscott-Mills, Tonya Steenhoff, Andrew P. Feemster, Kristen A. Shah, Samir S. Cunningham, Coleen K. Pelton, Stephen I. Kelly, Matthew S. PLoS One Research Article Pneumococcal conjugate vaccines reduce the burden of invasive pneumococcal disease, but the sustained effect of these vaccines can be diminished by an increase in disease caused by non-vaccine serotypes. To describe pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine (PCV-13) in July 2012, we performed molecular serotyping of 268 pneumococcal strains isolated from 221 children between 2012 and 2017. The median (interquartile range) age of the children included in this analysis was 6 (3,12) months. Fifty-nine percent of the children had received at least one dose of PCV-13 and 35% were fully vaccinated with PCV-13. While colonization by vaccine serotypes steadily declined following PCV-13 introduction, 25% of strains isolated more than 3 years after vaccine introduction were PCV-13 serotypes. We also observed an increase in colonization by non-vaccine serotypes 21 and 23B, which have been associated with invasive pneumococcal disease and antibiotic resistance in other settings. Public Library of Science 2022-01-05 /pmc/articles/PMC8730465/ /pubmed/34986196 http://dx.doi.org/10.1371/journal.pone.0262225 Text en © 2022 Patel et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Patel, Sweta M. Shaik-Dasthagirisaheb, Yazdani B. Congdon, Morgan Young, Rebecca R. Patel, Mohamed Z. Mazhani, Tiny Boiditswe, Sefelani Leburu, Tirayaone Lechiile, Kwana Arscott-Mills, Tonya Steenhoff, Andrew P. Feemster, Kristen A. Shah, Samir S. Cunningham, Coleen K. Pelton, Stephen I. Kelly, Matthew S. Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine |
title | Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine |
title_full | Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine |
title_fullStr | Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine |
title_full_unstemmed | Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine |
title_short | Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine |
title_sort | evolution of pneumococcal serotype epidemiology in botswana following introduction of 13-valent pneumococcal conjugate vaccine |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730465/ https://www.ncbi.nlm.nih.gov/pubmed/34986196 http://dx.doi.org/10.1371/journal.pone.0262225 |
work_keys_str_mv | AT patelswetam evolutionofpneumococcalserotypeepidemiologyinbotswanafollowingintroductionof13valentpneumococcalconjugatevaccine AT shaikdasthagirisahebyazdanib evolutionofpneumococcalserotypeepidemiologyinbotswanafollowingintroductionof13valentpneumococcalconjugatevaccine AT congdonmorgan evolutionofpneumococcalserotypeepidemiologyinbotswanafollowingintroductionof13valentpneumococcalconjugatevaccine AT youngrebeccar evolutionofpneumococcalserotypeepidemiologyinbotswanafollowingintroductionof13valentpneumococcalconjugatevaccine AT patelmohamedz evolutionofpneumococcalserotypeepidemiologyinbotswanafollowingintroductionof13valentpneumococcalconjugatevaccine AT mazhanitiny evolutionofpneumococcalserotypeepidemiologyinbotswanafollowingintroductionof13valentpneumococcalconjugatevaccine AT boiditswesefelani evolutionofpneumococcalserotypeepidemiologyinbotswanafollowingintroductionof13valentpneumococcalconjugatevaccine AT leburutirayaone evolutionofpneumococcalserotypeepidemiologyinbotswanafollowingintroductionof13valentpneumococcalconjugatevaccine AT lechiilekwana evolutionofpneumococcalserotypeepidemiologyinbotswanafollowingintroductionof13valentpneumococcalconjugatevaccine AT arscottmillstonya evolutionofpneumococcalserotypeepidemiologyinbotswanafollowingintroductionof13valentpneumococcalconjugatevaccine AT steenhoffandrewp evolutionofpneumococcalserotypeepidemiologyinbotswanafollowingintroductionof13valentpneumococcalconjugatevaccine AT feemsterkristena evolutionofpneumococcalserotypeepidemiologyinbotswanafollowingintroductionof13valentpneumococcalconjugatevaccine AT shahsamirs evolutionofpneumococcalserotypeepidemiologyinbotswanafollowingintroductionof13valentpneumococcalconjugatevaccine AT cunninghamcoleenk evolutionofpneumococcalserotypeepidemiologyinbotswanafollowingintroductionof13valentpneumococcalconjugatevaccine AT peltonstepheni evolutionofpneumococcalserotypeepidemiologyinbotswanafollowingintroductionof13valentpneumococcalconjugatevaccine AT kellymatthews evolutionofpneumococcalserotypeepidemiologyinbotswanafollowingintroductionof13valentpneumococcalconjugatevaccine |