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Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine

Pneumococcal conjugate vaccines reduce the burden of invasive pneumococcal disease, but the sustained effect of these vaccines can be diminished by an increase in disease caused by non-vaccine serotypes. To describe pneumococcal serotype epidemiology in Botswana following introduction of 13-valent p...

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Autores principales: Patel, Sweta M., Shaik-Dasthagirisaheb, Yazdani B., Congdon, Morgan, Young, Rebecca R., Patel, Mohamed Z., Mazhani, Tiny, Boiditswe, Sefelani, Leburu, Tirayaone, Lechiile, Kwana, Arscott-Mills, Tonya, Steenhoff, Andrew P., Feemster, Kristen A., Shah, Samir S., Cunningham, Coleen K., Pelton, Stephen I., Kelly, Matthew S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730465/
https://www.ncbi.nlm.nih.gov/pubmed/34986196
http://dx.doi.org/10.1371/journal.pone.0262225
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author Patel, Sweta M.
Shaik-Dasthagirisaheb, Yazdani B.
Congdon, Morgan
Young, Rebecca R.
Patel, Mohamed Z.
Mazhani, Tiny
Boiditswe, Sefelani
Leburu, Tirayaone
Lechiile, Kwana
Arscott-Mills, Tonya
Steenhoff, Andrew P.
Feemster, Kristen A.
Shah, Samir S.
Cunningham, Coleen K.
Pelton, Stephen I.
Kelly, Matthew S.
author_facet Patel, Sweta M.
Shaik-Dasthagirisaheb, Yazdani B.
Congdon, Morgan
Young, Rebecca R.
Patel, Mohamed Z.
Mazhani, Tiny
Boiditswe, Sefelani
Leburu, Tirayaone
Lechiile, Kwana
Arscott-Mills, Tonya
Steenhoff, Andrew P.
Feemster, Kristen A.
Shah, Samir S.
Cunningham, Coleen K.
Pelton, Stephen I.
Kelly, Matthew S.
author_sort Patel, Sweta M.
collection PubMed
description Pneumococcal conjugate vaccines reduce the burden of invasive pneumococcal disease, but the sustained effect of these vaccines can be diminished by an increase in disease caused by non-vaccine serotypes. To describe pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine (PCV-13) in July 2012, we performed molecular serotyping of 268 pneumococcal strains isolated from 221 children between 2012 and 2017. The median (interquartile range) age of the children included in this analysis was 6 (3,12) months. Fifty-nine percent of the children had received at least one dose of PCV-13 and 35% were fully vaccinated with PCV-13. While colonization by vaccine serotypes steadily declined following PCV-13 introduction, 25% of strains isolated more than 3 years after vaccine introduction were PCV-13 serotypes. We also observed an increase in colonization by non-vaccine serotypes 21 and 23B, which have been associated with invasive pneumococcal disease and antibiotic resistance in other settings.
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spelling pubmed-87304652022-01-06 Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine Patel, Sweta M. Shaik-Dasthagirisaheb, Yazdani B. Congdon, Morgan Young, Rebecca R. Patel, Mohamed Z. Mazhani, Tiny Boiditswe, Sefelani Leburu, Tirayaone Lechiile, Kwana Arscott-Mills, Tonya Steenhoff, Andrew P. Feemster, Kristen A. Shah, Samir S. Cunningham, Coleen K. Pelton, Stephen I. Kelly, Matthew S. PLoS One Research Article Pneumococcal conjugate vaccines reduce the burden of invasive pneumococcal disease, but the sustained effect of these vaccines can be diminished by an increase in disease caused by non-vaccine serotypes. To describe pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine (PCV-13) in July 2012, we performed molecular serotyping of 268 pneumococcal strains isolated from 221 children between 2012 and 2017. The median (interquartile range) age of the children included in this analysis was 6 (3,12) months. Fifty-nine percent of the children had received at least one dose of PCV-13 and 35% were fully vaccinated with PCV-13. While colonization by vaccine serotypes steadily declined following PCV-13 introduction, 25% of strains isolated more than 3 years after vaccine introduction were PCV-13 serotypes. We also observed an increase in colonization by non-vaccine serotypes 21 and 23B, which have been associated with invasive pneumococcal disease and antibiotic resistance in other settings. Public Library of Science 2022-01-05 /pmc/articles/PMC8730465/ /pubmed/34986196 http://dx.doi.org/10.1371/journal.pone.0262225 Text en © 2022 Patel et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Patel, Sweta M.
Shaik-Dasthagirisaheb, Yazdani B.
Congdon, Morgan
Young, Rebecca R.
Patel, Mohamed Z.
Mazhani, Tiny
Boiditswe, Sefelani
Leburu, Tirayaone
Lechiile, Kwana
Arscott-Mills, Tonya
Steenhoff, Andrew P.
Feemster, Kristen A.
Shah, Samir S.
Cunningham, Coleen K.
Pelton, Stephen I.
Kelly, Matthew S.
Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine
title Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine
title_full Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine
title_fullStr Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine
title_full_unstemmed Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine
title_short Evolution of pneumococcal serotype epidemiology in Botswana following introduction of 13-valent pneumococcal conjugate vaccine
title_sort evolution of pneumococcal serotype epidemiology in botswana following introduction of 13-valent pneumococcal conjugate vaccine
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730465/
https://www.ncbi.nlm.nih.gov/pubmed/34986196
http://dx.doi.org/10.1371/journal.pone.0262225
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