Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex

Enteroviruses are globally prevalent human pathogens responsible for many diseases. The nonstructural protein 2C is a AAA+ helicase and plays a key role in enterovirus replication. Drug repurposing screens identified 2C-targeting compounds such as fluoxetine and dibucaine, but how they inhibit 2C is...

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Detalles Bibliográficos
Autores principales: Hurdiss, Daniel L., El Kazzi, Priscila, Bauer, Lisa, Papageorgiou, Nicolas, Ferron, François P., Donselaar, Tim, van Vliet, Arno L.W., Shamorkina, Tatiana M., Snijder, Joost, Canard, Bruno, Decroly, Etienne, Brancale, Andrea, Zeev-Ben-Mordehai, Tzviya, Förster, Friedrich, van Kuppeveld, Frank J.M., Coutard, Bruno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730599/
https://www.ncbi.nlm.nih.gov/pubmed/34985963
http://dx.doi.org/10.1126/sciadv.abj7615

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730599/
https://www.ncbi.nlm.nih.gov/pubmed/34985963
http://dx.doi.org/10.1126/sciadv.abj7615

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