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Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring

Wearable technologies for personalized monitoring require sensors that track biomarkers often present at low levels. Cortisol—a key stress biomarker—is present in sweat at low nanomolar concentrations. Previous wearable sensing systems are limited to analytes in the micromolar-millimolar ranges. To...

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Autores principales: Wang, Bo, Zhao, Chuanzhen, Wang, Zhaoqing, Yang, Kyung-Ae, Cheng, Xuanbing, Liu, Wenfei, Yu, Wenzhuo, Lin, Shuyu, Zhao, Yichao, Cheung, Kevin M., Lin, Haisong, Hojaiji, Hannaneh, Weiss, Paul S., Stojanović, Milan N., Tomiyama, A. Janet, Andrews, Anne M., Emaminejad, Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730602/
https://www.ncbi.nlm.nih.gov/pubmed/34985954
http://dx.doi.org/10.1126/sciadv.abk0967
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author Wang, Bo
Zhao, Chuanzhen
Wang, Zhaoqing
Yang, Kyung-Ae
Cheng, Xuanbing
Liu, Wenfei
Yu, Wenzhuo
Lin, Shuyu
Zhao, Yichao
Cheung, Kevin M.
Lin, Haisong
Hojaiji, Hannaneh
Weiss, Paul S.
Stojanović, Milan N.
Tomiyama, A. Janet
Andrews, Anne M.
Emaminejad, Sam
author_facet Wang, Bo
Zhao, Chuanzhen
Wang, Zhaoqing
Yang, Kyung-Ae
Cheng, Xuanbing
Liu, Wenfei
Yu, Wenzhuo
Lin, Shuyu
Zhao, Yichao
Cheung, Kevin M.
Lin, Haisong
Hojaiji, Hannaneh
Weiss, Paul S.
Stojanović, Milan N.
Tomiyama, A. Janet
Andrews, Anne M.
Emaminejad, Sam
author_sort Wang, Bo
collection PubMed
description Wearable technologies for personalized monitoring require sensors that track biomarkers often present at low levels. Cortisol—a key stress biomarker—is present in sweat at low nanomolar concentrations. Previous wearable sensing systems are limited to analytes in the micromolar-millimolar ranges. To overcome this and other limitations, we developed a flexible field-effect transistor (FET) biosensor array that exploits a previously unreported cortisol aptamer coupled to nanometer-thin-film In(2)O(3) FETs. Cortisol levels were determined via molecular recognition by aptamers where binding was transduced to electrical signals on FETs. The physiological relevance of cortisol as a stress biomarker was demonstrated by tracking salivary cortisol levels in participants in a Trier Social Stress Test and establishing correlations between cortisol in diurnal saliva and sweat samples. These correlations motivated the development and on-body validation of an aptamer-FET array–based smartwatch equipped with a custom, multichannel, self-referencing, and autonomous source measurement unit enabling seamless, real-time cortisol sweat sensing.
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spelling pubmed-87306022022-01-19 Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring Wang, Bo Zhao, Chuanzhen Wang, Zhaoqing Yang, Kyung-Ae Cheng, Xuanbing Liu, Wenfei Yu, Wenzhuo Lin, Shuyu Zhao, Yichao Cheung, Kevin M. Lin, Haisong Hojaiji, Hannaneh Weiss, Paul S. Stojanović, Milan N. Tomiyama, A. Janet Andrews, Anne M. Emaminejad, Sam Sci Adv Physical and Materials Sciences Wearable technologies for personalized monitoring require sensors that track biomarkers often present at low levels. Cortisol—a key stress biomarker—is present in sweat at low nanomolar concentrations. Previous wearable sensing systems are limited to analytes in the micromolar-millimolar ranges. To overcome this and other limitations, we developed a flexible field-effect transistor (FET) biosensor array that exploits a previously unreported cortisol aptamer coupled to nanometer-thin-film In(2)O(3) FETs. Cortisol levels were determined via molecular recognition by aptamers where binding was transduced to electrical signals on FETs. The physiological relevance of cortisol as a stress biomarker was demonstrated by tracking salivary cortisol levels in participants in a Trier Social Stress Test and establishing correlations between cortisol in diurnal saliva and sweat samples. These correlations motivated the development and on-body validation of an aptamer-FET array–based smartwatch equipped with a custom, multichannel, self-referencing, and autonomous source measurement unit enabling seamless, real-time cortisol sweat sensing. American Association for the Advancement of Science 2022-01-05 /pmc/articles/PMC8730602/ /pubmed/34985954 http://dx.doi.org/10.1126/sciadv.abk0967 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Physical and Materials Sciences
Wang, Bo
Zhao, Chuanzhen
Wang, Zhaoqing
Yang, Kyung-Ae
Cheng, Xuanbing
Liu, Wenfei
Yu, Wenzhuo
Lin, Shuyu
Zhao, Yichao
Cheung, Kevin M.
Lin, Haisong
Hojaiji, Hannaneh
Weiss, Paul S.
Stojanović, Milan N.
Tomiyama, A. Janet
Andrews, Anne M.
Emaminejad, Sam
Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring
title Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring
title_full Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring
title_fullStr Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring
title_full_unstemmed Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring
title_short Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring
title_sort wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring
topic Physical and Materials Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730602/
https://www.ncbi.nlm.nih.gov/pubmed/34985954
http://dx.doi.org/10.1126/sciadv.abk0967
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