Allosteric modulation of the adenosine A(2A) receptor by cholesterol

Cholesterol is a major component of the cell membrane and commonly regulates membrane protein function. Here, we investigate how cholesterol modulates the conformational equilibria and signaling of the adenosine A(2A) receptor (A(2A)R) in reconstituted phospholipid nanodiscs. This model system conve...

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Detalles Bibliográficos
Autores principales: Huang, Shuya Kate, Almurad, Omar, Pejana, Reizel J, Morrison, Zachary A, Pandey, Aditya, Picard, Louis-Philippe, Nitz, Mark, Sljoka, Adnan, Prosser, R Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730723/
https://www.ncbi.nlm.nih.gov/pubmed/34986091
http://dx.doi.org/10.7554/eLife.73901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730723/
https://www.ncbi.nlm.nih.gov/pubmed/34986091
http://dx.doi.org/10.7554/eLife.73901

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