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Factors and reasons associated with low COVID-19 vaccine uptake among highly hesitant communities in the US
BACKGROUND: The inability to achieve high COVID-19 vaccination rates can continue to have serious harm to our communities. Vaccine hesitancy is a major barrier towards high vaccination rates. We evaluated the relationship between COVID-19 vaccine uptake and vaccine hesitancy, and then examined wheth...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730806/ https://www.ncbi.nlm.nih.gov/pubmed/34995722 http://dx.doi.org/10.1016/j.ajic.2021.12.013 |
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author | Khairat, Saif Zou, Baiming Adler-Milstein, Julia |
author_facet | Khairat, Saif Zou, Baiming Adler-Milstein, Julia |
author_sort | Khairat, Saif |
collection | PubMed |
description | BACKGROUND: The inability to achieve high COVID-19 vaccination rates can continue to have serious harm to our communities. Vaccine hesitancy is a major barrier towards high vaccination rates. We evaluated the relationship between COVID-19 vaccine uptake and vaccine hesitancy, and then examined whether community factors were associated with COVID-19 vaccine uptake and hesitancy. METHODS: We constructed and evaluated a cross-sectional, county-level dataset that included the levels of vaccination uptake and vaccine hesitancy, and population characteristics based on those included in the CDC's Social Vulnerability Index. RESULTS: Across 3142 US counties, vaccine hesitancy was significantly and negatively correlated with vaccine uptake rates (r = -0.06, P value <.01). The 2 predictors associated with a low vaccination level within highly hesitant communities were: no high school education (OR:0.70, P value <.001), and concern on vaccine availability and distribution (CVAC) (OR:0.00, P value <.001). The most common reason driving vaccine hesitancy was lack of trust in COVID-19 vaccines (55%), followed by concerns around side effects of the vaccine (48%), and lack of trust in government (46%). CONCLUSIONS: COVID-19 vaccine hesitancy is a public health threat. Our findings suggest that low education levels are a major contributor to vaccine hesitancy and ultimately vaccination levels. Since education levels are not easily modifiable, our results suggest that policymakers would be best served by closing knowledge gaps to overcome negative perceptions of the vaccine through tailored interventions. |
format | Online Article Text |
id | pubmed-8730806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87308062022-01-06 Factors and reasons associated with low COVID-19 vaccine uptake among highly hesitant communities in the US Khairat, Saif Zou, Baiming Adler-Milstein, Julia Am J Infect Control Major Article BACKGROUND: The inability to achieve high COVID-19 vaccination rates can continue to have serious harm to our communities. Vaccine hesitancy is a major barrier towards high vaccination rates. We evaluated the relationship between COVID-19 vaccine uptake and vaccine hesitancy, and then examined whether community factors were associated with COVID-19 vaccine uptake and hesitancy. METHODS: We constructed and evaluated a cross-sectional, county-level dataset that included the levels of vaccination uptake and vaccine hesitancy, and population characteristics based on those included in the CDC's Social Vulnerability Index. RESULTS: Across 3142 US counties, vaccine hesitancy was significantly and negatively correlated with vaccine uptake rates (r = -0.06, P value <.01). The 2 predictors associated with a low vaccination level within highly hesitant communities were: no high school education (OR:0.70, P value <.001), and concern on vaccine availability and distribution (CVAC) (OR:0.00, P value <.001). The most common reason driving vaccine hesitancy was lack of trust in COVID-19 vaccines (55%), followed by concerns around side effects of the vaccine (48%), and lack of trust in government (46%). CONCLUSIONS: COVID-19 vaccine hesitancy is a public health threat. Our findings suggest that low education levels are a major contributor to vaccine hesitancy and ultimately vaccination levels. Since education levels are not easily modifiable, our results suggest that policymakers would be best served by closing knowledge gaps to overcome negative perceptions of the vaccine through tailored interventions. Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. 2022-03 2022-01-05 /pmc/articles/PMC8730806/ /pubmed/34995722 http://dx.doi.org/10.1016/j.ajic.2021.12.013 Text en © 2022 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Major Article Khairat, Saif Zou, Baiming Adler-Milstein, Julia Factors and reasons associated with low COVID-19 vaccine uptake among highly hesitant communities in the US |
title | Factors and reasons associated with low COVID-19 vaccine uptake among highly hesitant communities in the US |
title_full | Factors and reasons associated with low COVID-19 vaccine uptake among highly hesitant communities in the US |
title_fullStr | Factors and reasons associated with low COVID-19 vaccine uptake among highly hesitant communities in the US |
title_full_unstemmed | Factors and reasons associated with low COVID-19 vaccine uptake among highly hesitant communities in the US |
title_short | Factors and reasons associated with low COVID-19 vaccine uptake among highly hesitant communities in the US |
title_sort | factors and reasons associated with low covid-19 vaccine uptake among highly hesitant communities in the us |
topic | Major Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730806/ https://www.ncbi.nlm.nih.gov/pubmed/34995722 http://dx.doi.org/10.1016/j.ajic.2021.12.013 |
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