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Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications
BACKGROUND: The worldwide corona virus disease outbreak, generally known as COVID-19 pandemic outbreak resulted in a major health crisis globally. The morbidity and transmission modality of COVID-19 appear more severe and uncontrollable. The respiratory failure and following cardiovascular complicat...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier GmbH.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730822/ https://www.ncbi.nlm.nih.gov/pubmed/35114450 http://dx.doi.org/10.1016/j.phymed.2022.153930 |
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author | Mukherjee, Pulok K Efferth, Thomas Das, Bhaskar Kar, Amit Ghosh, Suparna Singha, Seha Debnath, Pradip Sharma, Nanaocha Bhardwaj, Pardeep Kumar Haldar, Pallab Kanti |
author_facet | Mukherjee, Pulok K Efferth, Thomas Das, Bhaskar Kar, Amit Ghosh, Suparna Singha, Seha Debnath, Pradip Sharma, Nanaocha Bhardwaj, Pardeep Kumar Haldar, Pallab Kanti |
author_sort | Mukherjee, Pulok K |
collection | PubMed |
description | BACKGROUND: The worldwide corona virus disease outbreak, generally known as COVID-19 pandemic outbreak resulted in a major health crisis globally. The morbidity and transmission modality of COVID-19 appear more severe and uncontrollable. The respiratory failure and following cardiovascular complications are the main pathophysiology of this deadly disease. Several therapeutic strategies are put forward for the development of safe and effective treatment against SARS-CoV-2 virus from the pharmacological view point but till date there are no specific treatment regimen developed for this viral infection. PURPOSE: The present review emphasizes the role of herbs and herbs-derived secondary metabolites in inhibiting SARS-CoV-2 virus and also for the management of post-COVID-19 related complications. This approach will foster and ensure the safeguards of using medicinal plant resources to support the healthcare system. Plant-derived phytochemicals have already been reported to prevent the viral infection and to overcome the post-COVID complications like parkinsonism, kidney and heart failure, liver and lungs injury and mental problems. In this review, we explored mechanistic approaches of herbal medicines and their phytocomponenets as antiviral and post-COVID complications by modulating the immunological and inflammatory states. STUDY DESIGN: Studies related to diagnosis and treatment guidelines issued for COVID-19 by different traditional system of medicine were included. The information was gathered from pharmacological or non-pharmacological interventions approaches. The gathered information sorted based on therapeutic application of herbs and their components against SARSCoV-2 and COVID-19 related complications. METHODS: A systemic search of published literature was conducted from 2003 to 2021 using different literature database like Google Scholar, PubMed, Science Direct, Scopus and Web of Science to emphasize relevant articles on medicinal plants against SARS-CoV-2 viral infection and Post-COVID related complications. RESULTS: Collected published literature from 2003 onwards yielded with total 625 articles, from more than 18 countries. Among these 625 articles, more than 95 medicinal plants and 25 active phytomolecules belong to 48 plant families. Reports on the therapeutic activity of the medicinal plants belong to the Lamiaceae family (11 reports), which was found to be maximum reported from 4 different countries including India, China, Australia, and Morocco. Other reports on the medicinal plant of Asteraceae (7 reports), Fabaceae (8 reports), Piperaceae (3 reports), Zingiberaceae (3 reports), Ranunculaceae (3 reports), Meliaceae (4 reports) were found, which can be explored for the development of safe and efficacious products targeting COVID-19. CONCLUSION: Keeping in mind that the natural alternatives are in the priority for the management and prevention of the COVID-19, the present review may help to develop an alternative approach for the management of COVID-19 viral infection and post-COVID complications from a mechanistic point of view. |
format | Online Article Text |
id | pubmed-8730822 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier GmbH. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87308222022-01-06 Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications Mukherjee, Pulok K Efferth, Thomas Das, Bhaskar Kar, Amit Ghosh, Suparna Singha, Seha Debnath, Pradip Sharma, Nanaocha Bhardwaj, Pardeep Kumar Haldar, Pallab Kanti Phytomedicine Original Article BACKGROUND: The worldwide corona virus disease outbreak, generally known as COVID-19 pandemic outbreak resulted in a major health crisis globally. The morbidity and transmission modality of COVID-19 appear more severe and uncontrollable. The respiratory failure and following cardiovascular complications are the main pathophysiology of this deadly disease. Several therapeutic strategies are put forward for the development of safe and effective treatment against SARS-CoV-2 virus from the pharmacological view point but till date there are no specific treatment regimen developed for this viral infection. PURPOSE: The present review emphasizes the role of herbs and herbs-derived secondary metabolites in inhibiting SARS-CoV-2 virus and also for the management of post-COVID-19 related complications. This approach will foster and ensure the safeguards of using medicinal plant resources to support the healthcare system. Plant-derived phytochemicals have already been reported to prevent the viral infection and to overcome the post-COVID complications like parkinsonism, kidney and heart failure, liver and lungs injury and mental problems. In this review, we explored mechanistic approaches of herbal medicines and their phytocomponenets as antiviral and post-COVID complications by modulating the immunological and inflammatory states. STUDY DESIGN: Studies related to diagnosis and treatment guidelines issued for COVID-19 by different traditional system of medicine were included. The information was gathered from pharmacological or non-pharmacological interventions approaches. The gathered information sorted based on therapeutic application of herbs and their components against SARSCoV-2 and COVID-19 related complications. METHODS: A systemic search of published literature was conducted from 2003 to 2021 using different literature database like Google Scholar, PubMed, Science Direct, Scopus and Web of Science to emphasize relevant articles on medicinal plants against SARS-CoV-2 viral infection and Post-COVID related complications. RESULTS: Collected published literature from 2003 onwards yielded with total 625 articles, from more than 18 countries. Among these 625 articles, more than 95 medicinal plants and 25 active phytomolecules belong to 48 plant families. Reports on the therapeutic activity of the medicinal plants belong to the Lamiaceae family (11 reports), which was found to be maximum reported from 4 different countries including India, China, Australia, and Morocco. Other reports on the medicinal plant of Asteraceae (7 reports), Fabaceae (8 reports), Piperaceae (3 reports), Zingiberaceae (3 reports), Ranunculaceae (3 reports), Meliaceae (4 reports) were found, which can be explored for the development of safe and efficacious products targeting COVID-19. CONCLUSION: Keeping in mind that the natural alternatives are in the priority for the management and prevention of the COVID-19, the present review may help to develop an alternative approach for the management of COVID-19 viral infection and post-COVID complications from a mechanistic point of view. Elsevier GmbH. 2022-04 2022-01-05 /pmc/articles/PMC8730822/ /pubmed/35114450 http://dx.doi.org/10.1016/j.phymed.2022.153930 Text en © 2022 Elsevier GmbH. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Original Article Mukherjee, Pulok K Efferth, Thomas Das, Bhaskar Kar, Amit Ghosh, Suparna Singha, Seha Debnath, Pradip Sharma, Nanaocha Bhardwaj, Pardeep Kumar Haldar, Pallab Kanti Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications |
title | Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications |
title_full | Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications |
title_fullStr | Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications |
title_full_unstemmed | Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications |
title_short | Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications |
title_sort | role of medicinal plants in inhibiting sars-cov-2 and in the management of post-covid-19 complications |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8730822/ https://www.ncbi.nlm.nih.gov/pubmed/35114450 http://dx.doi.org/10.1016/j.phymed.2022.153930 |
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