A CLUSTER OF SARS‐COV‐2 DELTA VARIANT OF CONCERN ADDITIONALLY HARBORING F490S, NORTHERN LOMBARDY, ITALY

The Delta variant of concern (VOC) of SARS-CoV-2 has become dominant worldwide. In this article, we report a cluster caused by B.1.617.2 harboring the additional mutation of concern (MOC) F490S. We observed that 5 fully vaccinated subjects aged between 47 and 84 years were infected with this variant...

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Detalles Bibliográficos
Autores principales: Novazzi, Federica, Baj, Andreina, Pasciuta, Renee, Genoni, Angelo, Drago Ferrante, Francesca, Tripiciano, Rosalia, Catanoso, Giuseppe, Focosi, Daniele, Maggi, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8731264/
https://www.ncbi.nlm.nih.gov/pubmed/34995777
http://dx.doi.org/10.1016/j.ijid.2021.12.362
Descripción
Sumario:The Delta variant of concern (VOC) of SARS-CoV-2 has become dominant worldwide. In this article, we report a cluster caused by B.1.617.2 harboring the additional mutation of concern (MOC) F490S. We observed that 5 fully vaccinated subjects aged between 47 and 84 years were infected with this variant. The immune escape mutation F490S, first identified in the Lambda VOI, appears to impair vaccine efficacy and is rapidly increasing in prevalence worldwide.

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