The toxin mimic FS48 from the salivary gland of Xenopsylla cheopis functions as a Kv1.3 channel-blocking immunomodulator of T cell activation

The Kv1.3 channel has been widely demonstrated to play crucial roles in the activation and proliferation of T cells, which suggests that selective blockers could serve as potential therapeutics for autoimmune diseases mediated by T cells. We previously described that the toxin mimic FS48 from saliva...

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Detalles Bibliográficos
Autores principales: Zeng, Qingye, Lu, Wancheng, Deng, Zhenhui, Zhang, Bei, Wu, Jiena, Chai, Jinwei, Chen, Xin, Xu, Xueqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8732088/
https://www.ncbi.nlm.nih.gov/pubmed/34919963
http://dx.doi.org/10.1016/j.jbc.2021.101497

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